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Table 1 Comparison of patients with infection regarding disease severity

From: Sepsis recognition in the emergency department – impact on quality of care and outcome?

Variable

Total

Non-SIRS

Sepsis

Severe sepsis

P value

Case characteristics

 Number of patients, n (%)

110 (100)

56 (50.9)

34 (30.9)

20 (18.2)

 

 Age in years, median (IQR)

59 (44–73)

61 (39–75)

57 (45–70)

62 (50–74)

0.5

 Female sex, n (%)

46 (41.8)

25 (44.6)

14 (41.2)

7 (35.0)

0.8

 C-reactive protein in mg/dL, median (IQR)

8.6 (2.8–14.6)

5.6 (1.7–12.3)

10.7 (4.5–15.3)

18.4 (7.4–26.4)

<0.0001

 SIRS, mean/median (IQR)

1.6/1 (1–2)

0.6/1 (0–1)

2.5/2.5 (2–3)

2.7/2 (2–3)

<0.0001

 MEWS, mean/median (IQR)

2.3/2 (1–4)

1.2/1 (0–2)

3.1 (1–4)

4.2/4 (2.5–6)

<0.0001

 mMEDS, mean/median (IQR)

4.8/3 (2–8)

3.8/3 (0–5.5)

4.8/3 (2–9)

7.7/8 (4–11)

0.002

Focus of infection, n (%)

    

<0.0001

 Respiratory tract

27 (24.5)

11 (19.6)

8 (23.5)

8 (40)

 

 Gastrointestinal tract

18 (16.4)

12 (21.4)

5 (14.7)

1 (5)

 

 Urinary tract

18 (16.4)

6 (10.7)

7 (20.6)

5 (25)

 

 Skin/soft tissue

8 (7.3)

5 (8.9)

2 (5.9)

1 (5)

 

 Other

6 (5.5)

5 (8.9)

0 (0)

1 (5)

 

 Focus of infection

33 (30)

17 (30.4)

12 (35.3)

4 (20)

 

Organ dysfunctions, n (%)

 Present organ dysfunction

32 (29.1)

12 (21.4)

0 (0)

20 (100)

<0.0001

 More than one organ dysfunction

8 (7.3)

1 (1.8)

0 (0)

7 (35)

 
  1. Median and interquartile range reported for continuous variables and frequency; percentage reported for categorical variables. Differences between groups (non-SIRS vs. sepsis vs. severe sepsis) were analyzed by two-sided Kruskal-Wallis test or chi-square test as appropriate. Two-sided p-values <0.05 were considered statistically significant. BMI body mass index, MAP mean arterial pressure, SIRS systemic inflammatory response syndrome, MEWS Modified Early Warning Score, mMEDS modified Mortality in Emergency Department Sepsis Score, CCI Charlson Comorbidity Index (2010 version)