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Table 3 ROC curve results of CPR start time (NFT) and CPR to ECPR time (LFT) to predict outcomes

From: Prognostic effects of cardiopulmonary resuscitation (CPR) start time and the interval between CPR to extracorporeal cardiopulmonary resuscitation (ECPR) on patient outcomes under extracorporeal membrane oxygenation (ECMO): a single-center, retrospective observational study

 

Outcomes

AUC

(95% CI)

P-value

SN

(95% CI)

SP

(95% CI)

LR+

(95% CI)

LR-

(95% CI)

Youden Index

Cut-point

CPR start time (NFT)

CPR duration

(> 30 min vs. <30 min)

0.741

(0.595–0.857)

0.006*

50.00

(24.7–75.3)

93.75

(79.2–99.2)

8.00

(1.92–33.38)

0.53

(0.32–0.88)

0.437

≤ 3

ECMO length of stay

(≥ 2 days vs. <2 days)

0.669

(0.519–0.798)

0.034*

56.67

(37.4–74.5)

77.78

(52.4–93.6)

2.55

(1.02–6.39)

0.56

(0.35–0.90)

0.344

> 5

ICU length of stay

(≥ 3 days vs. <3 days)

0.717

(0.569–0.837)

0.003*

60.71

(40.6–78.5)

80.00

(56.3–94.3)

3.04

(1.20–7.66)

0.49

(0.29–0.82)

0.407

> 5

Hospital length of stay

(≥ 4 days vs. <4 days)

0.683

(0.533–0.810)

0.020*

62.50

(40.6–81.2)

75.00

(53.3–90.2)

2.50

(1.17–5.34)

0.50

(0.28–0.88)

0.375

> 5

28-day disability status

(with disability vs. without disability)

0.689

(0.394–0.901)

0.151

100

(47.8–100)

33.33

(7.5–70.1)

1.50

(0.95–2.38)

0

0.333

≤ 4

28-day neurological status

(poor status vs. good status)

0.656

(0.363–0.881)

0.335

88.89

(51.8–99.7)

40.00

(5.3–85.3)

1.48

(0.70–3.14)

0.28

(0.033–2.35)

0.288

≤ 4

ECMO survival

(yes vs. no)

0.776

(0.633–0.884)

0.0001*

94.12

(71.3–99.9)

64.52

(45.4–80.8)

2.65

(1.63–4.33)

0.091

(0.013–0.62)

0.586

≤ 5

24-h survival

(yes vs. no)

0.714

(0.566–0.835)

0.011*

77.42

(58.9–90.4)

70.59

(44.0-89.7)

2.63

(1.23–5.63)

0.32

(0.16–0.66)

0.480

≤ 7

28-day survival

(yes vs. no)

0.768

(0.624–0.877)

0.0001*

100

(76.8–100)

61.76

(43.6–77.8)

2.62

(1.71–4.01)

0

0.617

≤ 5

CPR to ECPR time (LFT)

CPR duration

(> 30 min vs. <30 min)

0.878

(0.751–0.955)

0.0001*

75.00

(47.6–92.7)

93.75

(79.2–99.2)

12.00

(3.04–47.29)

0.27

(0.11–0.63)

0.687

≤ 27

ECMO length of stay

(≥ 2 days vs. <2 days)

0.635

(0.484–0.769)

0.096

60.00

(40.6–77.3)

66.67

(41.0-86.7)

1.80

(0.88–3.68)

0.60

(0.35–1.04)

0.266

> 36

ICU length of stay

(≥ 3 days vs. <3 days)

0.696

(0.547–0.821)

0.010*

64.29

(44.1–81.4)

70.00

(45.7–88.1)

2.14

(1.04–4.42)

0.51

(0.29–0.91)

0.342

> 36

Hospital length of stay

(≥ 4 days vs. <4 days)

0.640

(0.488–0.773)

0.085

62.50

(40.6–81.2)

62.50

(40.6–81.2)

1.67

(0.91–3.04)

0.60

(0.33–1.10)

0.250

> 36

28-day disability status

(with disability vs. without disability)

0.500

(0.230–0.770)

0.999

20.00

(0.5–71.6)

55.56

(21.2–86.3)

0.45

(0.067–3.01)

1.44

(0.69–2.99)

0.244

< 39

28-day neurological status

(poor status vs. good status)

0.578

(0.294–0.828)

0.647

33.33

(7.5–70.1)

100

(47.8–100)

0

0.67

(0.42–1.06)

0.333

≤ 17

ECMO survival

(yes vs. no)

0.646

(0.495–0.779)

0.075

47.06

(23.0-72.2)

77.42

(58.9–90.4)

2.08

(0.91–4.75)

0.68

(0.42–1.11)

0.244

≤ 28

24-h survival

(yes vs. no)

0.538

(0.388–0.683)

0.661

29.03

(14.2–48.0)

88.24

(63.6–98.5)

2.47

(0.60-10.14)

0.80

(0.61–1.07)

0.172

≤ 22

28-day survival

(yes vs. no)

0.599

(0.447–0.738)

0.273

42.86

(17.7–71.1)

76.47

(58.8–89.3)

1.82

(0.77–4.29)

0.75

(0.46–1.22)

0.193

≤ 27

  1. Abbreviations; NFT: No flow time, LFT: Low flow time, CI: Confidence interval, SN: Sensitivity; SP: Specificity; LR+: Positive likelihood ratio; LR-: Negative likelihood ratio; *P-value < 0.05 considered significant