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Table 2 Decline in pain scores during the study

From: Comparing the efficacy of intravenous morphine versus ibuprofen or the combination of ibuprofen and acetaminophen in patients with closed limb fractures: a randomized clinical trial

Decline in pain, mean (CI)

Morphine (1)

Ibuprofen (2)

Ibuprofen-Acetaminophen (3)

p-value (1,2)

p-value (1,3)

p-value (2,3)

Decline in pain after 5 min

3.1 (2.7 to 3.5)

0.9 (0.6 to 1.2)

0.1 (0 to 0.2)

< 0.01

< 0.01

< 0.01

Decline in pain after 15 min

6.5 (6.1 to 6.9)

5.2 (4.8 to 5.6)

1.6 (1.3 to 1.9)

< 0.01

< 0.01

< 0.01

Decline in pain after 30 min

4.5 (3.8 to 5.2)

7.0 (6.6 to 7.4)

4.9 (4.4 to 5.4)

< 0.01

0.366

< 0.01

Decline in pain after 1 h

4.0 (3.4 to 4.6)

5.3 (4.8 to 5.8)

6.3 (5.9 to 6.7)

< 0.01

< 0.01

< 0.01