Table 1 30-day composite endpoint of the six outcome variables considered in the analysis

Sex

0.181

 Men

409,746 (48.1%)

245,545 (48.1%)

164,201 (48.2%)

 Women

441,903 (51.9%)

265,444 (51.9%)

176,459 (51.8%)

Age

60.0 (20.9)

60.0 (20.9)

60.1 (20.9)

0.156

 Age group

0.762

  18–34

125,493 (14.7%)

75,328 (14.7%)

50,165 (14.7%)

  35–44

104,704 (12.3%)

62,953 (12.3%)

41,751 (12.3%)

  45–54

110,938 (13.0%)

66,775 (13.1%)

44,163 (13.0%)

  55–64

112,484 (13.2%)

67,455 (13.2%)

45,029 (13.2%)

  65–74

133,879 (15.7%)

80,298 (15.7%)

53,581 (15.7%)

  75–84

150,794 (17.7%)

90,347 (17.7%)

60,447 (17.7%)

  84–94

104,504 (12.3%)

62,533 (12.2%)

41,971 (12.3%)

  >94

8853 (1.04%)

5300 (1.04%)

3553 (1.04%)

Income level

0.130

 High

3434 (0.40%)

2110 (0.41%)

1324 (0.39%)

 Medium

203,093 (23.8%)

121,749 (23.8%)

81,344 (23.9%)

 Low

594,152 (69.8%)

356,379 (69.7%)

237,773 (69.8%)

 Very Low

50,970 (5.98%)

30,751 (6.02%)

20,219 (5.94%)

GMA index score

0.543

 Baseline risk

68,083 (7.99%)

41,061 (8.04%)

27,022 (7.93%)

 Low risk

195,580 (23.0%)

117,297 (23.0%)

78,283 (23.0%)

 Moderate risk

281,024 (33.0%)

168,575 (33.0%)

112,449 (33.0%)

 High risk

203,696 (23.9%)

122,101 (23.9%)

81,595 (24.0%)

 Very high risk

103,266 (12.1%)

61,955 (12.1%)

41,311 (12.1%)

Number of drugs

6.14 (4.72)

6.14 (4.73)

6.15 (4.72)

0.614

 Antiacids (A02)

351,793 (41.3%)

211,112 (41.3%)

140,681 (41.3%)

0.872

 Osmotic Laxatives (A06AD)

2279 (0.27%)

1376 (0.27%)

903 (0.27%)

0.729

 Other Laxatives (A06X)

2524 (0.30%)

1498 (0.29%)

1026 (0.30%)

0.518

 Insulin (A10A)

53,248 (6.25%)

31,908 (6.24%)

21,340 (6.26%)

0.713

 Sulfonylides (A10BB)

19,334 (2.27%)

11,622 (2.27%)

7712 (2.26%)

0.754

 Gliptines (A10BH)

21,370 (2.51%)

12,925 (2.53%)

8445 (2.48%)

0.147

 Glyphosines and glinides (A10BX)

10,029 (1.18%)

6062 (1.19%)

3967 (1.16%)

0.366

 Other Oral antidiabetics (A10BX)

71,463 (8.39%)

42,778 (8.37%)

28,685 (8.42%)

0.428

 Vitamin K Antagonists (B01AA)

52,971 (6.22%)

31,713 (6.21%)

21,258 (6.24%)

0.527

 Heparin (B01AB)

37,724 (4.43%)

22,635 (4.43%)

15,089 (4.43%)

0.999

 Antiplatelet (B01AC)

154,251 (18.1%)

92,367 (18.1%)

61,884 (18.2%)

0.293

 Other antithrombotic (B01AX)

33,035 (3.88%)

19,891 (3.89%)

13,144 (3.86%)

0.426

 Digoxin (C01AA)

11,668 (1.37%)

6992 (1.37%)

4676 (1.37%)

0.875

 Antiarrhythmics (C01B)

19,508 (2.29%)

11,745 (2.30%)

7763 (2.28%)

0.557

 Antihypertensives (C02)

20,922 (2.46%)

12,474 (2.44%)

8448 (2.48%)

0.261

 Potassium Saving Agents (C03D)

26,609 (3.12%)

16,001 (3.13%)

10,608 (3.11%)

0.655

 Other diuretics (C03X)

140,610 (16.5%)

84,188 (16.5%)

56,422 (16.6%)

0.290

 Beta blockers (C07A)

143,490 (16.8%)

85,989 (16.8%)

57,501 (16.9%)

0.537

 Verapamil or diltiazem (C08D)

13,575 (1.59%)

8240 (1.61%)

5335 (1.57%)

0.095

 Other calcium antagonists (C08X)

85,654 (10.1%)

51,164 (10.0%)

34,490 (10.1%)

0.094

 IECA / ARA-II (C09)

257,782 (30.3%)

154,414 (30.2%)

103,368 (30.3%)

0.220

 Statins (C10AA)

195,564 (23.0%)

116,962 (22.9%)

78,602 (23.1%)

0.048

 Fibrates (C10AB)

13,480 (1.58%)

8156 (1.60%)

5324 (1.56%)

0.232

 Cotrimoxazole (D01AC01)

4970 (0.58%)

2958 (0.58%)

2012 (0.59%)

0.495

 Systemic corticosteroids (H02)

115,691 (13.6%)

69,158 (13.5%)

46,533 (13.7%)

0.098

 Beta-lactam antibiotics (J01DH)

1162 (0.14%)

693 (0.14%)

469 (0.14%)

0.825

 Other antibiotics (J01X)

268,849 (31.6%)

161,296 (31.6%)

107,553 (31.6%)

0.952

 Folic Acid Analogs (L01BA)

944 (0.11%)

579 (0.11%)

365 (0.11%)

0.421

 Tacrolimus (L04AD02)

5574 (0.65%)

3287 (0.64%)

2287 (0.67%)

0.119

 Other calcineurin inhibitors (L04AD)

690 (0.08%)

414 (0.08%)

276 (0.08%)

1.000

 Other immunosuppressants (L04X)

13,768 (1.62%)

8279 (1.62%)

5489 (1.61%)

0.756

 Anti-inflammatory (M01)

181,636 (21.3%)

108,899 (21.3%)

72,737 (21.4%)

0.658

 Opiacis (N02A)

135,176 (15.9%)

80,875 (15.8%)

54,301 (15.9%)

0.164

 Pyrazolones (N02BB)

137,802 (16.2%)

82,552 (16.2%)

55,250 (16.2%)

0.440

 Phenytoin (N03AB02)

1165 (0.14%)

678 (0.13%)

487 (0.14%)

0.220

 Carboxamide (N03AF)

7606 (0.89%)

4540 (0.89%)

3066 (0.90%)

0.587

 Valproic acid (N03AG01)

7452 (0.88%)

4449 (0.87%)

3003 (0.88%)

0.606

 Other antiepileptics (N03X)

86,398 (10.1%)

51,789 (10.1%)

34,609 (10.2%)

0.718

 Liti (N05AN01)

2180 (0.26%)

1342 (0.26%)

838 (0.25%)

0.143

 Other antipsychotics (N05AX)

73,728 (8.66%)

44,342 (8.68%)

29,386 (8.63%)

0.410

 Benzodiazepines (N05BA)

180,127 (21.2%)

108,302 (21.2%)

71,825 (21.1%)

0.222

 Other psycholeptics (N05X)

36,030 (4.23%)

21,563 (4.22%)

14,467 (4.25%)

0.549

 IRS Antidepressants (N06AB)

105,143 (12.3%)

63,293 (12.4%)

41,850 (12.3%)

0.164

 Other psychoanaleptics (N06AX)

72,004 (8.45%)

43,118 (8.44%)

28,886 (8.48%)

0.505