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Table 2 Meta-analysis of effects of rhAPC on 28-day mortality in patients with severe sepsis and APACHE II score of <25 at study entry

From: A meta-analysis of controlled trials of recombinant human activated protein C therapy in patients with sepsis

Clinical Trial

N

rhAPC

Control

RR

95% CI

p-Value

PROWESS

873

18.8

19.0

0.99

0.75–1.30

1.0 1

ADDRESS

2315

16.8

16.0

1.05

0.88–1.27

0.6 1

Total

3188

17.3

16.8

1.03

0.89–1.20

0.7 1,2,3

  1. 1 two-sided Fishers exact test
  2. 2 Cochran-Mantel-Haenszel test, p = 0.007
  3. 3 Breslow-Day test homogeneity, p = 0.007.
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BMC Emergency Medicine

ISSN: 1471-227X

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