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Table 2 Meta-analysis of effects of rhAPC on 28-day mortality in patients with severe sepsis and APACHE II score of <25 at study entry

From: A meta-analysis of controlled trials of recombinant human activated protein C therapy in patients with sepsis

Clinical Trial N rhAPC Control RR 95% CI p-Value
PROWESS 873 18.8 19.0 0.99 0.75–1.30 1.0 1
ADDRESS 2315 16.8 16.0 1.05 0.88–1.27 0.6 1
Total 3188 17.3 16.8 1.03 0.89–1.20 0.7 1,2,3
  1. 1 two-sided Fishers exact test
  2. 2 Cochran-Mantel-Haenszel test, p = 0.007
  3. 3 Breslow-Day test homogeneity, p = 0.007.