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Table 4 Summary of all the observational studies and randomized control trials with HFOV in adult patients

From: The initial Mayo Clinic experience using high-frequency oscillatory ventilation for adult patients: a retrospective study

       Baseline   
Author N Period CV (days) Paralysis APACHE II score PaO2/FiO2 OI Mortality (30 days) (%) Mortality (hospital) (%)
Mehta 156 1998–2002 5.6 90% 24 (1st day in ICU)* 91 31 62  
David 42 1998–2001 3.0† NR 28 (baseline)† 94† 23† 43 52
Mehta 24 1997–1999 5.7 22/24 22 (baseline) 99 33 67  
Fort 17 NR 5.1 All 23 (baseline) 66 49 53  
Andersen 16 1997–2001 7.2 11/16 27 (baseline) 92 28   31 (3 month)
Cartotto 6 1999–2000 4.8 All 16 92 32   83
Claridge 5 1998 NR All 29 52 NR   20
Derdak ‡ 75 1997–2000 2.8 All 22 (baseline) 114 24 37  
  73   4.4 NR 22 (baseline) 111 27 52  
Bollen ‡ 37 1997–2001 2.1 NR 21 (baseline) 96 25 43  
  24   1.5 NR 20 (baseline) 123 18 33  
Our cohort 14 2003–2004 1.7 13/14 36 (1st day in ICU)* 73 35 57 57
  1. Unless specified, data are presented as means. CV: conventional ventilation prior HFOV; OI: oxygenation index; NR: not reported
  2. * APACHE II before the institution of HFOV did not differ significantly from the first day in the ICU. † Median. ‡ Randomized controlled trials in adults. The upper and lower lines display the HFOV and CV arms respectively. In these two studies no significant differences among any of these variables were found, but for the OI in the study by Bollen et al.