BMC Emergency Medicine

Table 4 Summary of all the observational studies and randomized control trials with HFOV in adult patients

From: The initial Mayo Clinic experience using high-frequency oscillatory ventilation for adult patients: a retrospective study

						Baseline
Author	N	Period	CV (days)	Paralysis	APACHE II score	PaO₂/FiO₂	OI	Mortality (30 days) (%)	Mortality (hospital) (%)
Mehta	156	1998–2002	5.6	90%	24 (1st day in ICU)*	91	31	62
David	42	1998–2001	3.0†	NR	28 (baseline)†	94†	23†	43	52
Mehta	24	1997–1999	5.7	22/24	22 (baseline)	99	33	67
Fort	17	NR	5.1	All	23 (baseline)	66	49	53
Andersen	16	1997–2001	7.2	11/16	27 (baseline)	92	28		31 (3 month)
Cartotto	6	1999–2000	4.8	All	16	92	32		83
Claridge	5	1998	NR	All	29	52	NR		20
Derdak ‡	75	1997–2000	2.8	All	22 (baseline)	114	24	37
	73		4.4	NR	22 (baseline)	111	27	52
Bollen ‡	37	1997–2001	2.1	NR	21 (baseline)	96	25	43
	24		1.5	NR	20 (baseline)	123	18	33
Our cohort	14	2003–2004	1.7	13/14	36 (1st day in ICU)*	73	35	57	57

Unless specified, data are presented as means. CV: conventional ventilation prior HFOV; OI: oxygenation index; NR: not reported
* APACHE II before the institution of HFOV did not differ significantly from the first day in the ICU. † Median. ‡ Randomized controlled trials in adults. The upper and lower lines display the HFOV and CV arms respectively. In these two studies no significant differences among any of these variables were found, but for the OI in the study by Bollen et al.

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