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Table 5 Summary of previous studies

From: Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia

Anion Gap Studies
Study N Sensitivity Specificity ROC
Iberti et al[8] 56 21% Not Reported Not Reported
Levraut et al[10] 498 44% 91% 0.79
Moviat et al[18] 50 45% 16% Not Reported
Dinh et al[19] 356 39% 89% 0.76
Chawla et al[15] 285 15% 94% 0.55
Anion Gap Corrected for Albumin Studies
Study N Sensitivity Specificity ROC
Moviat et al[18] 50 100% 11% Not Reported
Dinh et al[19] 356 75% 59% 0.75
Chawla et al[15] 285 32% 80% 0.57
Base Deficit Studies
Study N Results
Mikulaschek et al[11] 52 No correlation between lactate and base deficit
Waters et al [11, 24] 12 Base deficit not useful, instead misleading
Chawla et al[15] 285 Base Deficit not useful, ROC AUC = 0.64
  1. ROC = Receiver operator characteristics area under the curve, AG = anion gap, ACAG = anion gap corrected for albumin, BD = Base Deficit, sensitivity and specificity for AG and ACAG are reported at threshold of 12
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