Table 3 Published cases of severe envenomation treated with FabAV

Bush 2002[10]

Patient 13^§

Altered mental status

Yes

6

Hypotension

Yes

Tachycardia

Yes

Neurotoxicity

Yes

SSS ≥ 7

Yes

Patient 14

Limb swelling

Yes

6

Limb pain

Yes

Hypotension

Yes

Tachycardia

Yes

SSS ≥ 7

Yes

Dart 1997[4]

Patient 10

SSS ≥ 7

Yes

8

Platelet count < 50,000/mm³

Yes

Fibrinogen < 50 mg/dl*

Yes

Lavonas 2004[25]

12-year-old Male

Compartment syndrome

Yes

4

Ruha 2002[13]

Patient 1

Limb swelling

Yes

18

Limb pain

Yes

Protime > 50 sec

Yes

Fibrinogen < 50 mg/dl*

Yes

Platelet count < 50,000/mm³

Yes

Offerman 2002[20]

First coagulopathy patient^†

Fibrinogen < 50 mg/dl*

Yes

NR

Second coagulopathy patient^†

Fibrinogen < 50 mg/dl*

Yes

NR

Platelet count < 50,000/mm³

Yes

Audi 2006[26]

80-year-old Female

Altered mental status

NR

6

Hypotension

Yes

SSS ≥ 7

Yes

Platelet count < 50,000/mm³

Yes

Camilleri 2005[27]

40-year-old Male

Limb swelling

Yes

N/A

Limb pain

NR

Bleeding

No

Clark 1997[22]

Case 1

Neurotoxicity

Yes

12

Case 3

Neurotoxicity

Yes

6

Fazelat 2008[28]

24-year-old Male

SSS ≥ 7

Yes

10

Platelet count < 50,000/mm³

Yes

Bleeding

No

Gold 2004[29]

38-year-old Male

Platelet count < 50,000/mm³

No

N/A

Horn 2007[30]

8-year-old Male

Compartment syndrome

No

N/A

Lintner 2006[31]

2-year-old Male

Limb swelling

Yes

12

Platelet count < 50,000/mm³

Yes

Miller 2002[32]

Case 1

Limb swelling

NR

NR

Platelet count < 50,000/mm³

Yes

Morgan 2006[33]

14-year-old Male

Airway swelling

Yes

NR

Altered mental status

Yes

Hypotension

Yes

Need for intubation

Yes

Bleeding

Yes

SSS ≥ 7

Yes

INR > 5.0

Yes

Odeleye 2004[34]

Case 1

Platelet count < 50,000/mm³

No

N/A

Case 2

Airway swelling

Yes

N/A

Need for intubation

Yes

INR > 5.0

Yes

Platelet count < 50,000/mm³

No

Offerman 2003[35]

42-year-old Male

Limb swelling

Yes

16

Limb pain

Yes

Bleeding

NR

Platelet count < 50,000/mm³

Yes

Richardson 2007[36]

Case 1

Need for intubation

No

N/A

Neurotoxicity

No

Case 2

Neurotoxicity

No

N/A

SSS ≥ 7

Yes

Platelet count < 50,000/mm³

Yes

Seifert 1997[37]

53-year-old Female

Platelet count < 50,000/mm³

Yes

6

Wasserberger 2006[38]

46-year-old Male

Limb swelling

No

N/A

Limb pain

No

Platelet count < 50,000/mm³

Yes