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Table 3 Published cases of severe envenomation treated with FabAV

From: Crotaline Fab antivenom appears to be effective in cases of severe North American pit viper envenomation: An integrative review

Publication Patient Identifying Information Severe venom effects Was Initial Control of this Venom Effect Achieved? Vials of FabAV for Initial Control
Cohort Studies
Prospective Data Collection
Bush 2002[10] Patient 13§ Altered mental status Yes 6
   Hypotension Yes  
   Tachycardia Yes  
   Neurotoxicity Yes  
   SSS ≥ 7 Yes  
  Patient 14 Limb swelling Yes 6
   Limb pain Yes  
   Hypotension Yes  
   Tachycardia Yes  
   SSS ≥ 7 Yes  
Dart 1997[4] Patient 10 SSS ≥ 7 Yes 8
   Platelet count < 50,000/mm3 Yes  
   Fibrinogen < 50 mg/dl* Yes  
Retrospective Data Collection
Lavonas 2004[25] 12-year-old Male Compartment syndrome Yes 4
Ruha 2002[13] Patient 1 Limb swelling Yes 18
   Limb pain Yes  
   Protime > 50 sec Yes  
   Fibrinogen < 50 mg/dl* Yes  
   Platelet count < 50,000/mm3 Yes  
Mixed Prospective + Retrospective Data Collection
Offerman 2002[20] First coagulopathy patient Fibrinogen < 50 mg/dl* Yes NR
  Second coagulopathy patient Fibrinogen < 50 mg/dl* Yes NR
   Platelet count < 50,000/mm3 Yes  
Non-Cohort Studies
Audi 2006[26] 80-year-old Female Altered mental status NR 6
   Hypotension Yes  
   SSS ≥ 7 Yes  
   Platelet count < 50,000/mm3 Yes  
Camilleri 2005[27] 40-year-old Male Limb swelling Yes N/A
   Limb pain NR  
   Bleeding No  
Clark 1997[22] Case 1 Neurotoxicity Yes 12
  Case 3 Neurotoxicity Yes 6
Fazelat 2008[28] 24-year-old Male SSS ≥ 7 Yes 10
   Platelet count < 50,000/mm3 Yes  
   Bleeding No  
Gold 2004[29] 38-year-old Male Platelet count < 50,000/mm3 No N/A
Horn 2007[30] 8-year-old Male Compartment syndrome No N/A
Lintner 2006[31] 2-year-old Male Limb swelling Yes 12
   Platelet count < 50,000/mm3 Yes  
Miller 2002[32] Case 1 Limb swelling NR NR
   Platelet count < 50,000/mm3 Yes  
Morgan 2006[33] 14-year-old Male Airway swelling Yes NR
   Altered mental status Yes  
   Hypotension Yes  
   Need for intubation Yes  
   Bleeding Yes  
   SSS ≥ 7 Yes  
   INR > 5.0 Yes  
Odeleye 2004[34] Case 1 Platelet count < 50,000/mm3 No N/A
  Case 2 Airway swelling Yes N/A
   Need for intubation Yes  
   INR > 5.0 Yes  
   Platelet count < 50,000/mm3 No  
Offerman 2003[35] 42-year-old Male Limb swelling Yes 16
   Limb pain Yes  
   Bleeding NR  
   Platelet count < 50,000/mm3 Yes  
Richardson 2007[36] Case 1 Need for intubation No N/A
   Neurotoxicity No  
  Case 2 Neurotoxicity No N/A
   SSS ≥ 7 Yes  
   Platelet count < 50,000/mm3 Yes  
Seifert 1997[37] 53-year-old Female Platelet count < 50,000/mm3 Yes 6
Wasserberger 2006[38] 46-year-old Male Limb swelling No N/A
   Limb pain No  
   Platelet count < 50,000/mm3 Yes  
  1. © This patient was also patient 6 in the Offerman, 2002 case series[20]
  2. Drs. Bush and Offerman have confirmed that these patients and patients 13 and 14 in the Bush series are not the same subjects.
  3. SSS = Snakebite Severity Score(Dart 96)
  4. INR = International Normalized Ratio
  5. NR = Not reported
  6. N/A = Not applicable (initial control not obtained)
  7. * Fibrinogen < 1.5 micromol/L