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Table 6 Recurrence or delayed onset of severe venom effects

From: Crotaline Fab antivenom appears to be effective in cases of severe North American pit viper envenomation: An integrative review

Publication Patient Identifying Information Vials of FabAV for Initial Control Maintenance Therapy Administered? Recurrent Severe Venom Effects Delayed Onset Severe Venom Effects
Cohort Studies
Prospective Data Collection
Bush 2002[10] Patient 14 6 Yes Limb swelling
Limb pain
None
Dart 1997[4] Patient 10 8 No Fibrinogen < 50 mg/dl None
Retrospective Data Collection
Ruha 2002[13] Patient 1 18 No Protime > 50 sec None
     Fibrinogen < 50 mg/dl  
Mixed Prospective/Retrospective Data Collection
No cases
Non-Cohort Studies
Camilleri 2005[27] 40-year-old Male N/A No None Platelet count < 50,000/mm3
INR >5
      Fibrinogen < 50 mg/dl
Fazelat 2008[28] 24-year-old Male 10 Yes Platelet count < 50,000/mm3 None
Lintner 2006[31] 2-year-old Male 12 No Platelet count < 50,000/mm3 None
Miller 2002[32] Case 1 NR No None Fibrinogen < 50 mg/dl
Odeleye 2004[34] Case 2 N/A No INR > 5.0 None
Offerman 2003[35] 42-year-old Male 16 NR Platelet count < 50,000/mm3 None
Richardson 2007[36] Case 1 N/A No None Fibrinogen < 50 mg/dl
Seifert 1997[37] 53-year-old Female 6 No Platelet count < 50,000/mm3 None
Wasserberger 2006[38] 46-year-old Male N/A No Platelet count < 50,000/mm3 None
  1. NR = Not reported
  2. N/A = Not applicable (initial control not obtained)