Fig. 2

Metabolite Interactions for Lactate. Interactions for the controlled node lactate in FS animals (left) and CPF animals (right). The controlled node lactate is shown in the ovals. Controlling nodes and their correlated signals are shown in boxes, with the controlling node in italics. Interaction weights between the controlled and controlling nodes are shown as arrows and numbers. Arrows are always directed from the controlling nodes to the controlled node to indicate that controlling nodes affect controlled nodes. The sign on the interaction weight associated with each arrow indicates the nature of the relationship. For positive interactions, an increase in the controlling node leads to an increase in the controlled node. For negative interactions, an increase in the controlling node leads to a decrease in the controlled node