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Table 2 Controlled nodes and controlling nodes for the FS (fasted) group

From: Metabolic networks in a porcine model of trauma and hemorrhagic shock demonstrate different control mechanism with carbohydrate pre-feed

Controlled node

Controlling node (sign)

Adenosine

Succinate (āˆ’); OPC (+)

Cytidine

Succinate (āˆ’); OPC (+); Lactate (āˆ’); Adenosine (āˆ’)

Glycerol

Uridine (+); Lactate (āˆ’)

Hypoxanthine

Succinate (āˆ’)

Lactate

BHB (āˆ’); OPC (+); Citrate (āˆ’); Creatine (āˆ’); Isobutyrate (āˆ’)

Uridine

Succinate (āˆ’); OPC (+); Glutamine (+)

  1. The sign indicates the direction of the interaction relative to the controlled node. (+) indicates that an increase in the level of the controlling node will lead to an increase in the controlled node; (āˆ’) indicates that an increase in the level of the controlling node will lead to a decrease in the controlled node
  2. BHB 3-hydroxybutyrate, OPC O-phosphocholine