Table 2 Performance of H-FABP with hs-cTnI and ECG
Test |  | AMI (n = 255) | No AMI (n = 845) | Total (n = 1100) | Proportion Negative Test (%) | Sensitivity (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
Optimal combinationa : ECG positive or hs-cTnI ≥10 ng/L or H-FABP ≥4.3 ng/mL | Positive | 246 | 392 | 638 |  | 99.2 (97.1 to 99.8) |  |
Negative | 2 | 439 | 441 | 40.9 | Â | 99.5 (98.4 to 99.9) | |
Hs-cTnI 99th percentile threshold: ECG positive or hs-cTnI ≥26 ng/L | Positive | 225 | 122 | 347 |  | 90.7 (86.5 to 93.7) |  |
Negative | 23 | 709 | 732 | 67.8 | Â | 96.9 (95.3 to 97.9) | |
Hs-cTnI or H-FABP 99th percentile threshold: ECG positive or hs-cTnI ≥26 ng/L or H-FABP ≥ 3.6 ng/mL | Positive | 244 | 442 | 686 |  | 98.4 (95.9 to 99.4) |  |
Negative | 4 | 389 | 393 | 36.4 | Â | 99.0 (97.4 to 99.6) | |
Hs-cTnI 99th percentile with H-FABP ROC derivedb: ECG positive or hs-cTnI ≥ 26 ng/L or H-FABP ≥ 3.1 ng/mL | Positive | 245 | 511 | 756 |  | 98.8 (96.5 to 99.6) |  |
Negative | 3 | 320 | 323 | 29.9 | Â | 99.1 (97.3 to 99.7) | |
Hs-cTnI threshold for >99.0 % sensitivity: ECG or hs-cTnI ≥ 3.9 ng/L | Positive | 246 | 456 | 702 |  | 99.2 (97.1 to 99.8) |  |
Negative | 2 | 375 | 377 | 34.9 | Â | 99.5 (98.1 to 99.9) |