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Table 2 Interventions

From: Design and rationale of the Procalcitonin Antibiotic Consensus Trial (ProACT), a multicenter randomized trial of procalcitonin antibiotic guidance in lower respiratory tract infection

CONSORT ProACT
Study arms
 Usual care All care and decisions by existing care providers
National LRTI guidelines disseminated
No procalcitonin provided
 Intervention All care and decisions by existing care providers
National LRTI guidelines disseminated
Procalcitonin provided in ED, and if hospitalized, 6–24 h later, and on Days 3, 5, 7. a
Standardization Standardized teaching material at start-up and refresher meetings, frequently asked questions, access to coordinating center and principal investigator 24/7
Study website, center visits and newsletters
Center monitoring
Adherence Regular adherence reports of procalcitonin sample time collection, time to clinician notification, procalcitonin guideline adherence, and feedback to individual centers
  1. ED emergency department, LRTI lower respiratory tract infection
  2. aserial blood draws only occur in hospitalized patients on antibiotics