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Table 2 Interventions

From: Design and rationale of the Procalcitonin Antibiotic Consensus Trial (ProACT), a multicenter randomized trial of procalcitonin antibiotic guidance in lower respiratory tract infection

CONSORT

ProACT

Study arms

 Usual care

All care and decisions by existing care providers

National LRTI guidelines disseminated

No procalcitonin provided

 Intervention

All care and decisions by existing care providers

National LRTI guidelines disseminated

Procalcitonin provided in ED, and if hospitalized, 6–24 h later, and on Days 3, 5, 7. a

Standardization

Standardized teaching material at start-up and refresher meetings, frequently asked questions, access to coordinating center and principal investigator 24/7

Study website, center visits and newsletters

Center monitoring

Adherence

Regular adherence reports of procalcitonin sample time collection, time to clinician notification, procalcitonin guideline adherence, and feedback to individual centers

  1. ED emergency department, LRTI lower respiratory tract infection
  2. aserial blood draws only occur in hospitalized patients on antibiotics
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BMC Emergency Medicine

ISSN: 1471-227X

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