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Table 1 Study characteristics

From: The effectiveness of prehospital hypertonic saline for hypotensive trauma patients: a systematic review and meta-analysis

Study Study Intervention Control
First author (year) Country Fluid (dose) Co-interventions Co-intervention fluid volume Mean (SD)a (L) Fluid (dose) Co-interventions Co-intervention fluid volume Mean (SD)a (L)
Bulger et al. (2011) [21] USA Canada 7.5% HS (250 ml) Fluid as per local protocol 1.31 (1.07)b 0.9% NS (250 ml) Fluid as per local protocol 1.16 (0.81)b
Jousi et al. (2010) [22] Finland 7.5% HS (300 ml) Ringer’s acetate and plasmafucin or hydroxyethylstarch 6% 0.8 (0.3–1.3)c Ringer’s acetate and Plasmafucin or hydroxyethylstarch 6%e NA 0.4 (0.2–0.5)d
Cooper et al. (2004) [23] Australia 7.5% HS (250 ml) LR or Haemacell (colloid) Total fluid: 1.3 (0.8–2.3)d Colloid: 0.5 (0.0–0.6)d LR (250 ml) LR or Haemacell (colloid) Total Fluid: 1.3 (0.8–2.3)d Colloid: 0.3 (0.0–0.5)d
Vassar et al. (1993a) [24] USA 7.5% HS (250 ml) “conventional isotonic fluids” Pre-intervention: 1.2 (1.1) Post-intervention: 1.0 (0.8) LR (250 ml) “conventional isotonic fluids” Pre-control: 1.3 (1.2) Post-control: 1.0 (0.9)
Vassar et al. (1993b) [25] USA 7.5% HS (250 ml) “conventional isotonic fluids” Pre-intervention: 0.3 (0.4) Post-intervention: 1.2 (0.8) 0.9% NS (250 ml) “conventional isotonic fluids” Pre-control: 0.3 (0.6) Post-control: 1.1 (0.8)
  1. Note: Co-intervention an intervention that is given either with the study intervention or control, HS hypertonic saline, LR Lactated Ringer’s solution, NA not available, NS normal saline
  2. aExcept where indicated; does not include intervention or control fluid
  3. bunclear if this includes intervention/control fluid
  4. cmean (range)
  5. dmedian (IQR)
  6. eThere was no explicit control dose provided, but rather routine care with the does outlined in the co-intervention fluid volume column