| | All patients (n = 588) | P-value | Quartile 1 (n = 147) | Quartile 2 (n = 147) | Quartile 3 (n = 147) | Quartile 4 (n = 147) | P for trend |
|---|
aSevere Multi-Organ Failure |
bN events (% of total) | 33 (5.6%) | | 1 (0.7%) | 2 (1.4%) | 6 (4.1%) | 24 (16.3%) | |
cOR (95% CI) | 3.6 (2.5–5.3) | < 0.001 | Reference | 2.1 (0.2–23.0) | 6.5 (0.8–55.2) | 29.9 (3.8–235.3) | < 0.001 |
28-Day All-Cause Mortality |
N events (% of total) | 50 (8.5%) | | 5 (3.4%) | 10 (6.8%) | 13 (8.8%) | 22 (15.0%) | |
OR (95% CI) | 1.5 (1.1–2.0) | =0.009 | Reference | 1.3 (0.4–4.0) | 1.5 (0.5–4.6) | 2.2 (0.8–6.5) | =0.079 |
- aSevere multi-organ failure defined as > 4 organ systems failing. Organ failure constitutes seven categories: [1] central nervous system, [2] circulatory failure, [3] respiratory failure, [4] kidney failure, [5] liver failure, [6] coagulopathy, [7] metabolic dysfunction. bN events (% of total) refers to the number of participants (proportion of total number participants) for each respective endpoint. cOR (95% CI) are expressed per one standard deviation (SD) increment of log-transformed penKid and in analyses of quartiles the lowest quartile (quartile 1) was defined as the reference category and the OR (95% CI) for each of quartiles 2, 3 and 4 were compared with the reference quartile. Analyses were adjusted for age, sex and eGFR calculated through the Modification of Diet in Renal Disease (MDRD) Study [18] formula
