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Fig. 4 | BMC Emergency Medicine

Fig. 4

From: BurnCare tablet trainer to enhance burn injury care and treatment

Fig. 4

Process flow of the BioGears inflammatory model in response to thermal injury. A TBSA input initiates the inflammatory cytokine kinetic model and generates a pain signal. The pain signal upregulates epinephrine production, which increases respiration rate and acts upon the BioGears cardiovascular model. The interaction of the pro- and anti-inflammatory compounds effects the integrity of the tissue (D) and produce the vasodilator nitric oxide (NO). The effects of tissue damage are modeled by reducing hydraulic resistance and increasing solute permeability on the connecting the vascular and interstitial regions of the BioGears cardiovascular circuit. These changes favor fluid loss to the interstitium, resulting in decreased blood volume and blood pressure. The baroreceptor and glomerular feedback models work to preserve blood pressure by increasing heart rate and systemic resistance and decreasing urine output

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