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Table 4 Regression Models

From: Propensity score adjusted comparison of three-factor versus four-factor prothrombin complex concentrate for emergent warfarin reversal: a retrospective cohort study

Factors OR (95% CI) P
Univariate Logistic Regression for INR Goal Met
 PCC4 14.44 (3.80–54.93) < 0.001
 Female 3.48 (1.36–8.90) 0.009
 Age 1.00 (0.98–1.03) 0.85
 Weight (kg) 1.00 (0.98–1.02) 0.71
 Dose (per 500 unit vial) 1.23 (0.92–1.63) 0.16
Bleed type
 Other Ref.  
 Intracranial 2.17 (0.70–6.68) 0.18
 Gastrointestinal 2.00 (0.45–8.94) 0.36
 Initial INR 0.78 (0.61–1.01) 0.06
 FFP units used 1.05 (0.67–1.63) 0.84
 Time from pre- to post-PCC INR (in hours) 1.28 (1.08–1.53) 0.005
 Survivors 1.12 (0.42–3.00) 0.82
 Length of stay, all 0.95 (0.88–1.03) 0.22
 Length of stay, survivors 0.94 (0.85–1.05) 0.27
 Thromboembolism, yes 0.43 (0.10–1.79) 0.25
PS Adjusted Logistic Regression AOR (95% CI)  
 PCC4 10.55 (2.17–51.24) < 0.001
Linear Regression Coefficient (95% CI)  
 Intercept (mean INR change PCC3) 1.64 (1.22–2.07) < 0.001
 mean INR change PCC4 0.91 (0.12–1.70) 0.03
 Intercept (post-PCC INR PCC3) 1.90 (1.69–2.12) < 0.001
 post-PCC INR PCC4 −0.51 (−0.91- -0.12) 0.01
PS Adjusted Linear Regression Coefficient (95% CI)  
 Intercept (mean INR change PCC3) 1.39 (0.89–1.89) < 0.001
 mean INR change PCC4 0.30 (−0.74–1.33) 0.56
 Intercept (post-PCC INR PCC3) 1.98 (1.73–2.23) < 0.001
 post-PCC INR PCC4 −0.45 (− 0.85- -0.19) 0.21
  1. AOR adjusted odds ratio, CI confidence interval, INR international normalized ratio, FFP fresh frozen plasma, NA not applicable, OR odds ratio, PCC prothrombin complex concentrate, PCC3 3-factor PCC, PCC4 4-factor PCC, PS propensity score, Ref. reference group