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Table 3 Hemogram hemogram-derived ratios findings. Median value. (interquartile range)

From: Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19

 

Total (n = 2254)

ICU (n = 185)

Non-ICU (n = 2069)

p value

Univariate analysis

OR (95% CI)

P value

Hemogram hemogram-derived ratio at admission

NLR

4.3 (2.7–8.0)

6.9 (4.0–11.7)

4.1 (2.6–7.6)

<  0.0001

1.03 (1.02–1.05)a

<  0.0001

PLR

1.9 (1.3–2.9)

2.0 (1.4–3.3)

1.9 (1.3–2.9)

0.023

1.13 (1.05–1.21)a

0.00057

NPR

2.3 (1.6–3.3)

3.0 (2.1–4.2)

2.3 (1.6–3.2)

<  0.0001

1.15 (1.09–1.22)a

<  0.0001

SII

9.2 (5.0–18.2)

13.0 (6.5–25.7)

9.0 (4.9–17.5)

<  0.0001

1.01 (1.01–1.02)a

0.00028

Positive rate of change (>  10% · day^-1)

NLR

20.9%

37.8%

19.4%

<  0.0001

1.87 (1.33–2.65)

0.00036

PLR

27.2%

35.7%

26.5%

0.33

NA

NA

NPR

42.7%

60%

41.1%

0.0029

1.74 (1.26–2.42)

0.00087

SII

30%

44.9%

28.7%

0.003

1.55 (1.11–2.19)

0.011

  1. aThe variable is continuous, the OR is for each increment in a unit. ICU-admitted vs Non-ICU admitted. The rate of change of the different inflammation ratios was obtained with up to four consecutive blood cells measurements since hospital entry. The rate of change was defined as the slope of the linear fit of the relative rates versus time from hospital entry in days. A rate of change higher than 10% per day was considered as positive.
  2. Abbreviations: ICU Intensive Care Unit, NLR neutrophil-lymphocyte ratio, PLR platelet-lymphocyte ratio, NPR neutrophil-platelets ratio, SII systemic immune-inflammation index