Table 1 Baseline characteristics according to the antibiotics prescribed before and after propensity score matching
Before propensity score matching | After propensity score matching | |||||
|---|---|---|---|---|---|---|
Guideline-concordant antibiotics (N = 359) | Guideline-discordant antibiotics (N = 271) | SD | Guideline-concordant antibiotics (N = 255) | Guideline-discordant antibiotics (N = 255) | SD | |
Age | 74.63 (11.56) | 76.85 (11.66) | 0.191 | 75.75 (11.16) | 76.81 (11.86) | 0.092 |
Sex (Male) | 245 (68.2) | 179 (66.1) | 0.047 | 170 (66.7) | 167 (65.5) | 0.025 |
Comorbidities | ||||||
Diabetes mellitus | 114 (31.8) | 83 (30.6) | 0.024 | 83 (32.5) | 80 (31.4) | 0.025 |
Hypertension | 190 (52.9) | 132 (48.7) | 0.084 | 129 (50.6) | 125 (49.0) | 0.031 |
Chronic obstructive lung disease | 43 (12.0) | 23 (8.5) | 0.115 | 24 (9.4) | 23 (9.0) | 0.014 |
Congestive heart failure | 12 (3.3) | 6 (2.2) | 0.068 | 8 (3.1) | 5 (2.0) | 0.075 |
Chronic kidney disease | 43 (12.0) | 35 (12.9) | 0.028 | 34 (13.3) | 34 (13.3) | < 0.001 |
Chronic liver disease | 30 (8.4) | 13 (4.8) | 0.144 | 15 (5.9) | 13 (5.1) | 0.034 |
Neoplastic diseases | 109 (30.4) | 69 (25.6) | 0.107 | 67 (26.3) | 67 (26.3) | < 0.001 |
Cerebrovascular disease | 104 (29.0) | 101 (37.3) | 0.177 | 84 (32.9) | 91 (35.7) | 0.058 |
Initial hemodynamic variables | ||||||
Mean arterial pressure (mmHg) | 88.51 (21.97) | 87.89 (21.03) | 0.029 | 87.53 (21.72) | 87.76 (21.28) | 0.011 |
Heart rate (beat/min) | 107.58 (25.38) | 104.27 (25.47) | 0.130 | 104.84 (25.10) | 104.76 (25.74) | 0.003 |
Respiratory rate (breath/min) | 24.89 (7.01) | 25.17 (7.08) | 0.040 | 24.82 (7.03) | 25.15 (7.02) | 0.046 |
Body temperature (°C) | 37.39 (1.16) | 37.15 (1.11) | 0.213 | 37.23 (1.15) | 37.19 (1.10) | 0.034 |
Laboratory results | ||||||
White blood cell (103/μL) | 11.26 (7.71) | 12.59 (7.71) | 0.172 | 12.14 (8.01) | 12.40 (7.58) | 0.033 |
Hemoglobin (g/dL) | 11.56 (2.31) | 11.39 (2.29) | 0.074 | 11.38 (2.41) | 11.45 (2.31) | 0.026 |
Platelet (103/μL) | 211.66 (110.39) | 218.59 (117.09) | 0.061 | 214.47 (110.81) | 216.12 (116.32) | 0.015 |
BUN (mg/dL) | 32.83 (22.78) | 38.66 (26.56) | 0.236 | 35.98 (24.99) | 38.00 (25.92) | 0.079 |
Creatinine (mg/dL) | 1.58 (1.59) | 1.69 (1.65) | 0.069 | 1.69 (1.80) | 1.69 (1.68) | 0.003 |
Albumin (g/dL) | 3.08 (0.55) | 3.00 (0.63) | 0.138 | 3.05 (0.55) | 3.00 (0.63) | 0.072 |
CRP (mg/dL) | 14.00 (9.11) | 12.58 (9.04) | 0.157 | 12.77 (8.68) | 12.69 (9.10) | 0.008 |
PSI score | 132.19 (34.63) | 140.03 (38.26) | 0.215 | 136.24 (35.43) | 139.08 (38.75) | 0.076 |
Multidrug-resistant pathogens isolateda | 32 (8.9) | 42 (15.5) | 0.202 | 30 (11.8) | 36 (14.1) | 0.070 |