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Table 2 Demographics, clinical characteristics and laboratory parameters of the target sample

From: Monocyte distribution width (MDW) as a new tool for the prediction of sepsis in critically ill patients: a preliminary investigation in an intensive care unit

Variables

Study Cohort

Target sample

Overall

Sepsis

 
 

No

Yes

p

N (%)

180 (100)

129 (100.0)

55 (43.0)

74 (57.0)

 

Categorical [N (%)]

 Male Gender

107 (59)

82 (63.6)

32 (58.0)

50 (68.0)

0.362

 Septic shock

21 (12)

21 (16.3)

–

21 (28.4)

–

 Bacteremia

58 (32.2)

58 (45.0)

5 (9.0)

53 (72.0)

< 0.001

 Mortality

46 (25)

40 (31.0)

11 (20.0)

29 (39.2)

0.03

Continuous Normal [mean (SD)]

 Age, years

63.7 (16.5)

62.40 (16.61)

63.11 (17.40)

61.86 (16.06)

0.680

 CCI

3.5 (2.3)

3.41 (2.40)

3.40 (2.50)

3.42 (2.30)

0.960

 SAPS II†

48.13 (15.1)

49.09 (15.06)

49.13 (13.70)

49.07 (16.07)

0.980

 SOFA†

6.8 (3.4)

7.23 (3.51)

6.22 (2.95)

7.99 (3.71)

0.003

 SOFA††

 

7.63 (3.52)

6.13 (2.69)

8.06 (3.63)

0.032

 Length of stay at ICU (days)

11.56 (8.26)

12.98 (8.87)

11.49 (6.96)

14.09 (9.96)

0.083

Continuous Non Normal [median (IQR)]

 MDW

 

23.00 (21.00–27.00)

21.00 (20.00–22.30)

25.60 (23.10–29.00)

< 0.001

 PCT, ng/mL

 

0.95 (0.19–9.8)

0.21 (0.12–0.91)

4.15 (0.60–27.00)

< 0.001

 CRP, mg/L

 

118.96 (55.28–190.70)

108.60 (41.64–159.6)

123.73 (60.57–218.13)

0.070

 WBCx103/μL

 

10.80 (8.00–15.40)

10.35 (8.17–14.35)

10.90 (7.80–15.80)

0.950

Categorical [N (%)]

 Main diagnoses at ICU admission

  Intracerebral haemorrhage

32 (17.8)

24 (18.6)

14 (25.5)

10 (13.5)

0.135

  Cardiovascular failure

26 (14.4)

19 (14.7)

10 (18.2)

9 (12.2)

0.482

  Polytrauma

23 (12.8)

19 (14.7)

9 (16.4)

10 (13.5)

0.841

  Respiratory failure

20 (11.1)

11 (8.5)

3 (5.5)

8 (10.8)

0.448

  Acute ischemic Stroke

16 (8.9)

12 (9.3)

8 (14.5)

4 (5.4)

0.144

  Acute kidney failure

10 (5.6)

5 (3.9)

1 (1.8)

4 (5.4)

0.560

  Head trauma

9 (5.0)

6 (4.7)

3 (5.5)

3 (4.1)

1.0

  Brain surgery

9 (5.0)

5 (3.9)

3 (5.5)

2 (2.7)

0.734

  Acidosis in metformin use

5 (2.8)

3 (2.3)

1 (1.8)

2 (2.7)

1.0

  Septic shock

4 (2.2)

4 (3.1)

0 (0.0)

4 (5.4)

0.215

  Haemorrhagic shock

4 (2.2)

3 (2.3)

0 (0.0)

3 (4.1)

0.357

  Peritonitis

3 (1.7)

3 (2.3)

0 (0.0)

3 (4.1)

0.357

  Acute pancreatitis

2 (1.1)

2 (1.6)

0 (0.0)

2 (2.7)

0.611

  Coma in encephalitis

2 (1.1)

2 (1.6)

0 (0.0)

2 (2.7)

0.611

  Consequence of Duodeno-cephalo-Pancreatectomy

1 (0.6)

1 (0.8)

0 (0.0)

1 (1.4)

1.0

  Anaphylactic shock

1 (0.6)

1 (0.8)

0 (0.0)

1 (1.4)

1.0

  Other

13 (7.2)

9 (7.0)

3 (5.5)

6 (8.1)

0.813

  1. CCI Charlson Comorbidity Index, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, PCT Procalcitonin; CRP: C-Reactive Protein; MDW Monocyte Distribution Width, WBC White Blood Cell Count; †at ICU admission; ††at sepsis diagnosis, available for 58 patients
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