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Table 4 Predictive diagnostic accuracy of MOD on day 2 with qSOFA and additional Interleukin-6, Interleukin-8, Procalcitonin

From: Risk prediction of biomarkers for early multiple organ dysfunction in critically ill patients

 

AUC(95%CI)

Improvement of AUC

P-value

NRI (95%CI)

P-value

Sensitivity

Specificity

PPV

NPV

qSOFA (Day-0)

0.728 (0.651–0.794)

   

64.2

66.2

73.5

55.8

qSOFA (Day-0) + IL-6(Day-0)

0.765 (0.685–0.830)

0.037 (0.001–0.073)

0.252

0.562 (0.267–0.857)

0.001*

83.2

56.9

73.8

69.8

qSOFA (Day-0) + IL-6(Day-1)

0.842 (0.771–0.893)

0.113 (0.053–0.174)

0.002*

0.802 (0.520–1.084)

< 0.001*

74.7

86.2

88.8

70.0

qSOFA (Day-0) + PCT (Day-0)

0.814 (0.740–0.870)

0.086 (0.033–0.138)

0.008*

0.661 (0.362–0.959)

< 0.001*

82.1

64.6

77.2

71.2

qSOFA (Day-0) + PCT (Day-1)

0.785 (0.707–0.847)

0.057 (0.011–0.103)

0.084

0.492 (0.188–0.797)

0.009*

67.4

76.9

81.0

61.7

qSOFA (Day-0) + IL-8(Day-0)

0.793 (0.716–0.854)

0.061 (0.016–0.105)

0.044*

0.502 (0.198–0.806)

0.007*

78.9

67.2

78.1

68.3

qSOFA (Day-0) + IL-8(Day-1)

0.829 (0.758–0.882)

0.100 (0.045–0.155)

0.002*

0.784 (0.494–1.073)

< 0.001*

71.6

78.5

82.9

65.4

qSOFA (Day-1)

0.801 (0.723–0.861)

   

58.1

83.1

83.1

58.1

qSOFA (Day-1) + IL-6(Day-1)

0.868 (0.799–0.915)

0.067 (0.025–0.108)

0.005*

0.712 (0.423–1.001)

< 0.001*

89.2

70.8

81.4

82.1

qSOFA (Day-1) + PCT (Day-1)

0.842 (0.765–0.897)

0.041 (0.009–0.073)

0.037*

0.503 (0.201–0.805)

0.003*

78.5

80.0

84.9

72.2

qSOFA (Day-1) + IL-8(Day-1)

0.881 (0.816–0.925)

0.080 (0.039–0.121)

< 0.001*

0.718 (0.423–1.013)

< 0.001*

92.5

69.2

81.1

86.5

  1. AUC Area under the curve, CI Confidence interval, IL Interleukin, NRI Net reclassification improvement, qSOFA Quick squential organ failure assessment, PPV positive predictive value, NPV Negative predictive value
  2. If the NRI is positive and the 95%CI does not straddle zero, the predictive ability of the new model is considered to be significantly improved from the baseline model