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Table 4 INR change, initial/baseline INR, and INR post-PCC

From: Comparison of 3-factor versus 4-factor prothrombin complex concentrate for emergent warfarin reversal: a systematic review and meta-analysis

Study, Year

INR change PCC3

INR change PCC4

Initial/baseline INR in PCC3 group

Post-PCC dose INR in the PCC3 group

Initial/baseline INR in PCC4 group

Post-PCC dose INR in the PCC4 group

Al-Majzoub et al., 2016 [20]

0.9 (0.5)

1.8 (1.5)

2.3 (0.6), NR [NR]

1.4 (0.2), NR [NR]

3.0 (1.5), NR [NR]

1.2 (0.1), NR [NR]

DeAngelo et al., 2018 [22]

NR

NR

NR (NR), 2.6 [2.2–3.7]

NR

NR (NR), 2.6 [2.0–3.4]

NR

Fischer et al., 2018 [24]

NR

NR

NR (NR), 2.8 [2.3–3.7]

NR (NR), 1.3 [1.2–1.5]

NR (NR), 2.6 [2.2–3.1]

NR (NR), 1.2 [1.2–1.4]

Holt et al., 2018 [25]

NR

NR

3.61 (2.3), NR [NR]

1.40 (0.27), NR [NR]

6.87 (2.3), NR [NR]

1.25 (0.33), NR [NR]

Jones et al., 2016 [27]

NR

NR

NR (NR), 2.6 [2.2–3.5]

NR (NR), 1.3 [1.2–1.4]

NR (NR), 3.0 [2.2–4.6]

NR (NR), 1.2 [1.1–1.4]

Kuroski et al., 2017 [28]

NR

NR

NR (NR), 3.15 (1.6–19) range

NR (NR), 1.4 [1.1–2.6]

NR (NR), 3.1 (2–19) range

NR (NR), 1.3 [1–1.8]

Mangram et al., 2016 [30]

NR

NR

3.1 (2.3), NR [NR]

1.6 (0.6), NR [NR]

3.4 (3.7), NR [NR]

1.3 (0.2), NR [NR]

Margraf et al., 2020 [31]

1.1 [0.6–2.0]

2.3 [1.2–3.3]

2.8 [2.1–4.1]

1.7 [1.5–2.0]

3.7 [2.6–4.9]

1.3 [1.3–1.4]

Mohan et al., 2018 [32]

2.80 (2.33) (median = 2.13)

3.23 (3.48) (median = 1.85)

4.64 (2.88), 3.72 [NR]

1.85 (0.92), 1.50 [NR]

4.54 (3.45), 3.05 [NR]

1.30 (0.20), 1.3 [NR]

Voils et al., 2015 [33]

1.4 (NR)

2.2 (NR)

3.0 (NR), 2.5 [2.0–3.2]

1.6 (NR)

3.5 (NR), 2.4 [2.0–4.2]

1.3 (NR)

Cang et al., 2014 [21]

NR

NR

NR

NR

NR

NR

Di Napoli et al., 2014 [23]

NR

NR

NR

NR

NR

NR

Kotsianas et al., 2015 [26]

NR

NR

3.44 (1.99)

NR

3.86 (2.50)

NR

Peck et al., 2016 [29]

1.26 (1.11)

3.6 (4.16)

NR

NR

NR

NR

Wagner et al., 2019 [34]

NR

NR

NR

1.5

NR

1.4

  1. mean (SD), median [IQR]
  2. INR international normalized ratio, NR not reported, PCC prothrombin complex concentrate, PCC3 3 factor PCC, PCC4 4 factor PCC