Table 5 Timing of PCC administration
Study, Year | Time between initial INR and PCC dose PCC3 | Time between initial INR and PCC dose PCC4 | Time between PCC and second INR PCC3 | Time between PCC dose and second INR PCC4 |
|---|---|---|---|---|
Al-Majzoub et al., 2016 [20] | NR | NR | 5.0 (7.4) hours | 3.7 (4) hours |
DeAngelo et al., 2018 [22] | NR | NR | NR (88%) | NR (97%) |
Fischer et al., 2018 [24] | NR | NR | NR | NR |
Holt et al., 2018 [25] | NR | NR | 3.8 (0.12) hours | 3.3 (0.10) hours |
Jones et al., 2016 [27] | NR | NR | 48:59 [31:00–91:00] min:sec | 23:40 [15:33–90:00] min:sec |
Kuroski et al., 2017 [28] | 37.9 (28.3) minutes | 42.7 (27) minutes | 191 (195) minutes | 169 (230) minutes |
Mangram et al., 2016 [30] | NR | NR | 3 [0.6–16.5] hours | 4.2 [0.6–18.9] hours |
Margraf et al., 2020 [31] | 78 [56.0–113.0] minutes | 73 [40.0–108.5] minutes | 93 [46.0–228.0] minutes | 226 [156.5–368.5] minutes |
Mohan et al., 2018 [32] | NR | NR | 3 h (both groups) | 3 h (both groups) |
Voils et al., 2015 [33] | NR | NR | NR | NR |
Cang et al., 2014 [21] | NR | NR | NR | NR |
Di Napoli et al., 2014 [23] | NR | NR | NR | NR |
Kotsianas et al., 2015 [26] | NR | NR | 217 (247) minutes | 208 (187) minutes |
Peck et al., 2016 [29] | NR | NR | NR | NR |
Wagner et al., 2019 [34] | NR | NR | NR | NR |