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Table 7 Scenario results: per protocol by comparator

From: Evaluation of the effectiveness and costs of inhaled methoxyflurane versus usual analgesia for prehospital injury and trauma: non-randomised clinical study

Comparison

Predicted Pain Pathway

Duration in severe pain

Time to least pain

Level of least pain

  

Time (mins)

p-value

Time (mins)

p-value

Pain

p-value

Methoxyflurane

\(0.763+I\left\{t\ge 0.5\right\}[0.868\text{\hspace{0.05em}}-0.211t+0.004{t}^{2}]\)

10.54 (se = 0.70)

-

26.94 (se = 0.74)

 < 0.001

-1.97 (se = 0.18)

 < 0.001

 vs Entonox®

\(0.763+I\left\{t\ge 0.5\right\}\left[0.799\text{\hspace{0.05em}}-0.072t+0.001{t}^{2}\right]\)

a

44.96 (se = 2.49)

-0.82 (se = 0.18)

Methoxyflurane

\(0.441+I\left\{t\ge 0.5\right\}[0.540\text{\hspace{0.05em}}-0.200t+0.004{t}^{2}]\)

10.47 (se = 0.69)

 < 0.001

27.00 (se = 0.75)

 < 0.001

-2.16 (se = 0.20)

0.010

 vs Morphine IV

\(0.441+I\left\{t\ge 1\right\}\left[0.550\text{\hspace{0.05em}}-0.111t+0.001{t}^{2}\right]\)

20.09 (se = 1.12)

42.77 (se = 1.48)

-1.81 (se = 0.19)

Methoxyflurane

\(0.896+I\left\{t\ge 0.5\right\}[1.002\text{\hspace{0.05em}}-0.214t+0.004{t}^{2}]\)

9.66 (se = 0.68)

 < 0.001

27.07 (se = 0.76)

 < 0.001

-1.89 (se = 0.28)

 < 0.001

 vs Paracetamol IV

\(0.896+I\left\{t\ge 5\right\}\left[1.328\text{\hspace{0.05em}}-0.091t+0.001{t}^{2}\right]\)

37.53 (se = 6.58)

45.77 (se = 3.11)

-0.76 (se = 0.29)

  1. aNot predicted to exit severe pain