Role of CD8+ T cell exhaustion in the progression and prognosis of acute respiratory distress syndrome induced by sepsis: a prospective observational study

Table 3 The clinical scores and exhaustion-related markers for predicting 90-day mortality

Variables	ROC curve			Sensitivity (%)	Specificity (%)	Youden index (%)
Variables	AUC (95% CI)	Best cutoff	p	Sensitivity (%)	Specificity (%)	Youden index (%)
Lymphocytes	0.688(0.535-0.842)	8.75	0.023	64.40	76.50	40.90
CD8⁺ T cell	0.761(0.623-0.898)	6.47	0.002	73.30	70.60	43.90
PD-1	0.659(0.510-0.807)	5.90	0.055	40.00	88.2	28.20
Tim-3	0.745(0.615-0.875)	16.55	0.003	68.90	70.60	39.50
APACHE II Scores	0.752(0.623-0.880)	11.50	0.002	68.90	70.60	39.50
SOFA Scores	0.770(0.633-0.907)	5.50	0.001	75.60	70.60	46.20
LIPS Scores	0.839(0.742-0.937)	7.50	0.000	66.70	94.10	60.80

Abbreviations: PD-1, Programmed Cell Death 1; Tim-3, T-cell immunoglobulin mucin-3; APACHE, Acute Physiology and Chronic Evaluation; SOFA, Sequential Organ Failure Assessment; LIPS, Lung Injury Prediction Score; ROC, Receiver operating characteristics; AUC, area under the curve

ISSN: 1471-227X