Table 2 The mean number of vaso-occlusive crises (VOCs) and levels of hemoglobin (Hgb), hematocrit (HCT), platelet counts (PLT Ct), and reticulocyte count (%) before the initiation of hydroxyurea and 12 months later
Variable | Baseline, mean ± SD | 12–Month follow-up, mean ± SD | Mean difference | 95% Confidence limits for mean difference | p–value |
|---|---|---|---|---|---|
VOCs | 2.13 ± 2.94 | 0.77 ± 1.23 | 1.36 ± 2.11 | 1.03–1.70 | < 0.0001 |
Hgb (g/L) | 85.62 ± 16.52 | 87.17 ± 24.04 | −1.83 ± 23.72 | −2.06–5.72 | 0.3534 |
HCT (%) | 26.05 ± 6.30 | 26.44 ± 7.51 | −0.49 ± 8.66 | −0.93 ± 1.91 | 0.4964 |
PLT Ct | 383.13 ± 192.27 | 394.76 ± 202.96 | −15.58 ± 178.5 | −44.87–13.72 | 0.2951 |
Reticulocyte count (%) | 10.31 ± 12.87 | 0.722 ± 2.27 | 10.07 ± 16.63 | 4.08–16.07 | 0.007 |