Variables | Subgroup | Number of patients | Events (death) | HR ratio (95%CI) | p value | p for interaction |
---|---|---|---|---|---|---|
Age (years) | 0.586 | |||||
< 65 | 1388 | 612 | 1.367 (1.164–1.605) | < 0.001 | ||
≥ 65 | 2086 | 1026 | 1.325 (1.172–1.498) | < 0.001 | ||
Sex | 0.168 | |||||
Female | 1304 | 531 | 1.210 (1.020–1.435) | 0.028 | ||
Male | 2170 | 1107 | 1.415 (1.256–1.593) | < 0.001 | ||
Renal disease | 0.588 | |||||
No | 2586 | 1268 | 1.328 (1.189–1.483) | < 0.001 | ||
Yes | 888 | 370 | 1.433 (1.163–1.765) | 0.001 | ||
COPD | 0.167 | |||||
No | 3258 | 1531 | 1.361 (1.230–1.506) | < 0.001 | ||
Yes | 216 | 107 | 1.031 (0.705–1.508) | 0.877 | ||
Lymphoma/leukaemia | 0.575 | |||||
No | 3287 | 1513 | 1.316 (1.189–1.456) | < 0.001 | ||
Yes | 187 | 125 | 1.420 (0.985–2.048) | 0.060 | ||
Moderate or severe liver disease | 0.004 | |||||
No | 3304 | 1519 | 1.361 (1.230–1.506) | < 0.001 | ||
Yes | 170 | 119 | 0.806 (0.560–1.159) | 0.245 | ||
APACHE II score* | 0.765 | |||||
≤ 23.00 | 737 | 275 | 1.388 (1.095–1.760) | 0.007 | ||
> 23.00 | 2737 | 1363 | 1.315 (1.182–1.463) | < 0.001 | ||
Blood transfusion | 0.248 | |||||
No | 1766 | 688 | 1.219 (1.039–1.429) | 0.015 | ||
Yes | 1708 | 950 | 1.082 (0.939–1.246) | 0.275 | ||
Platelet (103/µL)* | 0.128 | |||||
< 173.8 | 1737 | 990 | 1.359 (1.197–1.542) | < 0.001 | ||
≥ 173.8 | 1737 | 648 | 1.187 (1.017–1.384) | 0.029 | ||
Blood urea nitrogen (mg/dL)* | 0.799 | |||||
< 27.0 | 1707 | 691 | 1.326 (1.142–1.540) | < 0.001 | ||
≥ 27.0 | 1767 | 947 | 1.279 (1.124–1.455) | < 0.001 | ||
Creatinine (mg/dL)* | 0.699 | |||||
< 1.2 | 1660 | 700 | 1.289 (1.111–1.494) | 0.001 | ||
≥ 1.2 | 1814 | 938 | 1.305 (1.145–1.486) | < 0.001 |