Point-of-care testing in Paediatric settings in the UK and Ireland: a cross-sectional study

Background Point-of-care testing (POCT) is diagnostic testing performed at or near to the site of the patient. Understanding the current capacity, and scope, of POCT in this setting is essential in order to respond to new research evidence which may lead to wide implementation. Methods A cross-sectional online survey study of POCT use was conducted between 6th January and 2nd February 2020 on behalf of two United Kingdom (UK) and Ireland-based paediatric research networks (Paediatric Emergency Research UK and Ireland, and General and Adolescent Paediatric Research UK and Ireland). Results In total 91/109 (83.5%) sites responded, with some respondents providing details for multiple units on their site based on network membership (139 units in total). The most commonly performed POCT were blood sugar (137/139; 98.6%), urinalysis (134/139; 96.4%) and blood gas analysis (132/139; 95%). The use of POCT for Influenza/Respiratory Syncytial Virus (RSV) (45/139; 32.4%, 41/139; 29.5%), C-Reactive Protein (CRP) (13/139; 9.4%), Procalcitonin (PCT) (2/139; 1.4%) and Group A Streptococcus (5/139; 3.6%) and was relatively low. Obstacles to the introduction of new POCT included resources and infrastructure to support test performance and quality assurance. Conclusion This survey demonstrates significant consensus in POCT practice in the UK and Ireland but highlights specific inequity in newer biomarkers, some which do not have support from national guidance. A clear strategy to overcome the key obstacles of funding, evidence base, and standardising variation will be essential if there is a drive toward increasing implementation of POCT. Supplementary Information The online version contains supplementary material available at 10.1186/s12873-021-00556-7.


Background
There is a need for clinicians to make accurate and timely decisions regarding emergency management of their patients. Laboratory tests are often used, in conjunction with clinical findings, to determine the most appropriate care pathway. Delays in obtaining and reporting urgent samples can lead to department crowding, protracted discharge times, and failure to deliver optimal patient care in emergency and acute care settings [1][2][3]. Point-Of-Care Testing (POCT) has the potential to provide rapid and accurate results that reduce such delays [4][5][6]. Potential additional benefits include improved clinical management, treatment adherence, and patient satisfaction [5] which must be balanced against the clinical significance of time gained. For example, in the context of an over crowded department with long waiting times does a 15 min time to result improve outcomes for patients? Also there are concerns regarding reliability and cost of POCT compared with centralised laboratory testing, and appropriate governance of POCT. There is currently no clearly described consensus approach to procurement, implementation and governance of POCT in the UK and Ireland; similar lack of consensus is evident in medical literature internationally [7][8][9][10][11].
However emerging evidence and ongoing research continue to evaluate the potential impact of POCT. Should these tests prove to have good clinical utility, they are likely to be incorporated into national guidance, and clinical practice, more widely. Developing a framework for the clinical use, implementation, and governance of POCT is therefore essential within the healthcare system, especially those aiming to prioritise same day emergency care. It remains the case that many Emergency Departments serve both adult and paediatric populations, and POCT may serve the needs of both patient groups. This works well for test common to both age categories (such as glucose) but perhaps not so well for respiratory testing which is anecdotally more common place in paediatric practice. As no survey of POCT has previously been performed across Children's Acute and Emergency Care, it is important to establish whether this is truly the case, across a widely inclusive range of POCTs.
The primary aim of this study was to describe POCT in current use in acute paediatric settings across the UK and Ireland. Secondary objectives were to examine implementation, maintenance, funding and governance and further opinions on the introduction of new POCT including obstacles and enablers.

Methods
This online cross sectional survey was conducted between 6th January and 2nd February 2020, and is reported in accordance with the Checklist for Reporting Results of Internet E-Surveys (CHERRIES [12]).
Existing literature on use of POCT in acute paediatric settings [9][10][11] informed the initial survey content, which was subsequently refined iteratively by the study team. In the absence of international guidance, content was finalised by consensus of the study team following external review, and prior to launch the survey underwent external piloting. This rationlised the number of questions and determined the range of POCTs to be surveyed. The survey was distributed to member sites of the General Adolescent and Paediatric Research in the UK & Ireland (GAPRUKI) and Paediatric Emergency Research in the UK & Ireland (PERUKI [13]) networks, with one response for each relevant emergency or acute paediatric unit requested from each network site (not all sites were members of both networks). Responses could be provided on behalf of Emergency Departments, Paediatric Assessment Units, Paediatric ward settings, and Urgent Care Centres.
For the purposes of this survey, POCT was defined as an investigative or diagnostic test utilised by staff in a clinical environment, for which results are available in a short time (within 30 min) to aid clinical decision making in that setting (i.e. not at a later date/time). Additional detail in this definition stated that they should be performed and interpreted by clinical staff caring for the patient, not sent elsewhere for other personnel to analyse and interpret, and should require no other interpretation (i.e. the result is binary, sequential or categorical).
The full survey, available in Appendix 1, included questions on availability of a range of POCT across clinical settings. Adaptive questioning was used, and where applicable, respondents were asked questions on personnel performing and interpreting tests, and POCT governance. All respondents were asked to provide the view of their site on the potential benefits and challenges presented by the concept of expanding POCT use, and were asked to describe any obstacles or enablers from previous experience of implementing POCT. Responses were collected in Research Electronic Data Capture tools (REDCap [14,15]), and were held on a secure University of Bristol server. We followed a standard framework; open for 4 weeks with non-responders sent reminders with 2 weeks to go, 1 week to go, and 48 h to go. Responses were analysed anonymously by the study team using Microsoft Excel version 16.42). Data are presented using descriptive statistics, including number and proportion for categorical variables.
As this survey study contained no patient level data, and was distributed using professional collaborative professional networks, ethical approval was unnecessary according to the Health Research Authority framework decision tool [16] .

Results
In total, 109 invites were sent, to which there were 91 (83.5%) responses across 139 units (Fig. 1, each clinician could respond for more than one unit on their site), contributing data regarding 72 Emergency Departments (including Observation Units), 28 Paediatric Assessment Units, 34 Paediatric Inpatient wards, and five Urgent Care Centres.
A description of staff types performing and interpreting tests is provided in Table 2; this is further quantified by clinical area in Supplementary Tables 5 and 6. As multiple staff groups could be selected for each POCT for each unit, there was a total of 2132 responses relating to staff roles in performance of POCT, and 3097 relating to actioning of results. Clinical nurses were the staff group most commonly responsible for POCT performance (705/2132; 33.1%) followed by Emergency Nurse Practitioners (ENP)/Advanced Nurse Practitioners (ANP) (435/2132, 20.4%) and junior doctors (385/2132; 18.1%). POCT were mostly acted on by senior nonconsultants (736/3097; 23.8%), consultants (736/3097; 23.8%) and junior trainees (702/3097; 22.7%). Table 3, with 561 responses related to governance, and 677 responses related to data storage.

Discussion
We have demonstrated a diverse range of POCT in use in Children's Emergency Departments and Assessment units. Some POCT, such as blood sugar testing, blood ketone testing, blood gas analysis and urinalysis are fairly commonplace, whilst "newer" POCT such as CRP and Procalcitonin were uncommon. Despite this penetrance of POCT into acute units, we have also identified wide variation in their governance, and usage processes. The challenge of identifying the optimal governance of POCT appears to hinder their implementation, as do a current lack of evidence, and cost; these elements are particularly important when considering introducing POCT to national guidance if emerging evidence supports their use.
Respiratory POCT were utilised in under half the responding units, with Respiratory Syncytial Virus (RSV) and influenza usage at 33.3 and 40.3% respectively. POCT for RSV has previously been evaluated and found to be a safe, cost-effective, and efficient way to improve bed management [17]. The lack of widespread utilisation is, therefore, perhaps surprising. However, some centres cohort infants with bronchiolitis based on symptoms, in which case POCT may conversely delay admission. A formal evaluation of these two approaches would help determine the utility of POCT in this situation. However, it must be recognised that determining viral aetiology is useful for public health surveillance and it is likely that ward based testing will still need to occur.
For influenza, one study of the use of POCT in febrile children showed no difference in physician management, cost, or length of stay in the paediatric Emergency Department (ED) [7]. However, a positive POCT for influenza was associated with a significant reduction in urine and blood cultures being sent for febrile children [18].
Some studies have recommended use of rapid streptococcal A infection testing for patients with a sore throat, citing reduction of antimicrobial use [19,20]. However, in England, this is not routinely recommended by National Institute of Health and Care Excellence (NICE) guidance, as this approach is unlikely to be costeffective. Their limited role in improving antimicrobial prescribing and stewardship, as well as patient outcomes, when compared to clinical scores alone [21] is the likely reason for the low use in surveyed sites.
In relation to biomarkers for infection, a systematic review and cost-effectiveness analysis evaluated whether Procalcitonin testing was helpful in guiding antibiotic therapy for sepsis in intensive care and ED settings [22,23]. This concluded that addition of a Procalcitonin based algorithm to antibiotic guidance could be useful in reducing antibiotic exposure and length of hospital stay safely in adults [22]. Clinicians might infer that similar results may be seen in children, however high quality evidence is lacking, and further research is needed on the utility of Procalcitonin in this domain.
The most common source of funding for POCT was sustainable long term funding as part of an ongoing service commitment for well-established POCT; these included blood gas analysis, urinalysis and blood sugar testing, and are routinely used in > 90% of departments. The newer POCT were more likely to be funded using temporary funds as part of a service evaluation, through charitable funding and/ or donations or as part of an industry sponsored trial.
Given our findings regarding the challenges of implementing new POCT, robust evidence for patient benefit is required in order to provide a clear case to justify National Health Service (NHS) spending on the testing equipment and consumables required to use in routine clinical practice.
We acknowledge the limitations of a survey based qualitative study but believe our response rate and reach were sufficient to avoid significant bias. We acknowledge that some operator training and quality control have been identified as barriers to adoption and we didn't ask focused questions on these. This was a point-in-time survey and it is likely that the situation in many departments may be different now than at the time the survey  POCT Point-of-Care Test, hCG human Chorionic Gonadotrophin, RSV Respiratory Syncytial Virus, CRP C-reactive protein was undertaken. However we hope our identification of domains of interests will be useful for future evaluation and research.
In summary, if new POCT are to be introduced, it is vital that all stakeholders are involved in the decision making including clinical and laboratory teams, patients, regulatory authorities and insurers. Sustainability will depend on sound evidence base and financial viability [24].

Conclusions
The use of POCT for blood glucose, blood gas, urinalysis and blood ketones is widespread among UK Children's Emergency Departments and Assessment units, however newer biomarkers tests are used less often, including those for pathogen identification. Variation exists both in unit practices, and the governance of POCT. A clear strategy to overcome the key obstacles of funding, evidence base, and standardising variation will be essential if there is a drive toward increasing implementation of POCT.