Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop

Table 2 Search Strategy

Database	Pub Med	Ovid Medline	EMBASE
Dates searched	1/1/1990 - 12/31/2009	1/1/1990 - 12/31/2009	1990 - 2009
Search terms employed (all connected by logical "OR" function)	MeSH headings:	MeSH headings:
	Crotalid venoms/PO [poisoning]	Crotalid venoms/PO [poisoning]	Crotalid venoms AND [intoxication OR toxicity]
	Crotalid venoms/TO [toxicity]	Crotalid venoms/TO [toxicity]	Snake venoms AND [intoxication OR toxicity]
	Snake venoms/PO	Snake venoms/PO	Snake bites AND [drug therapy OR therapy]
	Snake venoms/TO	Snake venoms/TO
	Snake bites/DT [drug therapy]	Snake bites/DT [drug therapy]	Viperidae
	Snake bites/TH [therapy]	Snake bites/TH [therapy]	Agkistrodon
	Viperidae	Viperidae	Crotalus
	Agkistrodon	Agkistrodon	FabAV
	Crotalus	Crotalus	Crotaline immune Fab
	Keywords	Keywords
	CroFab	CroFab
	Crotaline immune Fab	Crotaline immune Fab
Citations retrieved	1230	1097	1711

Searches were conducted on January 6, 2010 and were limited to English language and humans. After removal of 1,748 duplicate citations, 339 additional citations were excluded based on the keywords rat(s), mouse, mice, rabbit(s), cellular, in vivo, or in vitro. Hand-search of the titles and abstracts of the remaining 1,951 citations yielded 91 citations that appeared to contain original data about crotaline snake envenomation patients who were either treated with Fab antivenom or managed without antivenom. Full-text copies of these 91 articles and abstracts were obtained and made available to the project team in a computer data file. Of these, 42 articles and abstracts were identified as containing data relevant to the key questions identified in preliminary panel discussions. These 42 references were reproduced and made available during the in-person panel meeting.

ISSN: 1471-227X