Studying the therapeutic effects of hemoperfusion with continuous venovenous hemofiltration in paraquat-poisoned patients by the ratio of residual normal lung in 3D-CT image
- Liu Peng†1,
- Zhang Hong-tao†2,
- Liang Yu-guang3,
- He Jin1,
- Li Yue-qi1,
- Li Gong-jie2Email author and
- Zhou Yue-su1Email author
© Peng et al; licensee BioMed Central Ltd. 2012
Published: 18 December 2012
Paraquat poisoning(PQ) by ingestion is often fatal and is a significant public health problem worldwide.The lung is the major target organ for PQ poisoning. The study is aimed to investigate the ratio of residual normal lung in 3D-CT image in evaluating the therapic effects of continuous venovenous hemofiltration(CVVH).
Nighty-five patients with acute paraquat poisoning were randomly divided into hemoperfusion(HP) group (46 cases) and HP-CVVH group (49 cases). The mortality, survival duration and the ratio of residual normal lung in 3D-CT image between the two groups were compared and analyzed.
There were no significant differences in mortality (28.26% versus 24.49%) between the two groups on day 28 after poisoning. The mean time between poisoning and death in HP-CVVH group was (5.2±2.1) days, which was significantly longer than that (3.8±1.7) days in HP group (P<0.05). The ratio of residual normal lung in 3D-CT image on 6th day after poisoning in HP-CVVH group was (31.80±12.71)%,which was significantly higher than that (25.60±14.06)% in HP group (P < 0.05).
The combined therapy of HP and CVVH could prevent advances in lung injury induced by acute paraquat poisoning and prolong survival time, but failed to reduce mortality of paraquat-poisoned patients.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.