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Effect of the Xuebijing oral solution on survival of rabbits with acute paraquat poisoning

Objective

To study the effect of the Xuebijing oral solution on survival of rabbits with acute paraquat poisoning.

Methods

30 New Zealand white rabbits were randomly divided into saline control group(group A) and two treatment groups of 3ml/kg(group B) and 10ml/kg(group C) of Xuebijing oral solution.All the rabbits were treated with PQ at 35mg/kg through intraperitoneal injection, which would build the model of acute poisoning. Group B and C were treated by gavage with 3ml/kg and 10ml/kg of Xuebijing oral solution respectively, once a day to maintain. Group A were treated with saline instead.

Results

The analysis of survival curve showed that the survival rate was not significantly different between group A and B, but group C was significantly higher than group A and B(P<0.05).

Conclusion

Large doses of Xuebijing oral solution may improve the survival rate of acute paraquat poisoning.

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Correspondence to Chen Gao-fei.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zu-jun, S., Gao-fei, C., Guo-kun, A. et al. Effect of the Xuebijing oral solution on survival of rabbits with acute paraquat poisoning. BMC Emerg Med 12 (Suppl 1), A6 (2012). https://doi.org/10.1186/1471-227X-12-S1-A6

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  • DOI: https://doi.org/10.1186/1471-227X-12-S1-A6

Keywords

  • Public Health
  • Treatment Group
  • Survival Rate
  • Emergency Medicine
  • Survival Curve