Volume 12 Supplement 1
Effect of the Xuebijing oral solution on survival of rabbits with acute paraquat poisoning
© Zu-jun et al; licensee BioMed Central Ltd. 2012
Published: 18 December 2012
To study the effect of the Xuebijing oral solution on survival of rabbits with acute paraquat poisoning.
30 New Zealand white rabbits were randomly divided into saline control group(group A) and two treatment groups of 3ml/kg(group B) and 10ml/kg(group C) of Xuebijing oral solution.All the rabbits were treated with PQ at 35mg/kg through intraperitoneal injection, which would build the model of acute poisoning. Group B and C were treated by gavage with 3ml/kg and 10ml/kg of Xuebijing oral solution respectively, once a day to maintain. Group A were treated with saline instead.
The analysis of survival curve showed that the survival rate was not significantly different between group A and B, but group C was significantly higher than group A and B(P<0.05).
Large doses of Xuebijing oral solution may improve the survival rate of acute paraquat poisoning.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.