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Clinical usefulness of T-SPOT.TB in the diagnosis tuberculosis in emergency patients

Objective

To evaluate the diagnostic value of an interferon-gamma release assay T-SPOT.TB in tuberculosis of emergency patients.

Methods

The emergency patients with suspected tuberculosis received T-SPOT.TB assay in the peripheral blood mononuclear cells(PBMCs).

Results

T-SPOT.TB assay, PPD, anti-TB antibody test, M tuberculosis polymerase chain reaction, acid-fast bacilli stain and cultures for M tuberculosis were positive in 96.8%(31/32), 43.7%(14/32), 21.8%(7/32), 15.6%(5/32), 13.0%(3/23) and 4.3%(1/23), respectively, of patients with active tuberculosis. The sensitivity and specificity of the T-SPOT.TB were 96.8% and 98.3%.

Conclusions

T-SPOT.TB assay is a rapid and high-sensitive tests for diagnosing tuberculosis in emergency patients.

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Corresponding author

Correspondence to YIN Wen.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xiao-min, H., Jian, L., Long, L. et al. Clinical usefulness of T-SPOT.TB in the diagnosis tuberculosis in emergency patients. BMC Emerg Med 12 (Suppl 1), A7 (2012). https://doi.org/10.1186/1471-227X-12-S1-A7

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  • DOI: https://doi.org/10.1186/1471-227X-12-S1-A7

Keywords

  • Polymerase Chain Reaction
  • Tuberculosis
  • Mononuclear Cell
  • Peripheral Blood Mononuclear Cell
  • Clinical Usefulness