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Table 4 Empiric antibiotic treatment and targeted organisms in microbiologic culture

From: All purulence is local – epidemiology and management of skin and soft tissue infections in three urban emergency departments

A. Culture results
  Pediatric Adult
  MRSA% Other result% MRSA% Other result%
Anti-MRSA therapy only 52.6 47.4 34.5 65.5
B     
  Culture results
  Pediatric Adult
MSSA% Other result% MSSA% Other result%
Anti-MSSA therapy only 37.5 72.5 35 65
C.     
  Culture results
  Pediatric Adult
MRSA% MSSA% Other result% MRSA% MSSA% Other result%
Double Coverage 62.5 37.5 0.0 44.3 21.5 34.2
  1. MSSA = methicillin-sensitive S. aureus; MRSA = methicillin-resistant S. aureus.
  2. NB : Patients (63 pediatric, 189 adult) with skin and soft tissue infections (SSTIs) that were cultured in the ED and who received antibiotics are shown, with pediatric and adult patients considered separately. Tables are separated by empiric therapy given and the culture result targeted. 4A: Patients who were treated with empiric anti-MRSA antibiotics only. 4B: Patients who were treated with empiric anti-MSSA antibiotics only. 4C: Patients who were treated with double coverage (treatment with two or more antibiotics with gram-positive coverage).
  3. Anti-MRSA antibiotics include antibiotics typically active against community-acquired (CA-) MRSA: trimethoprim-sulfamethoxazole, tetracycline, doxycycline, clindamycin, rifampin, linezolid or vancomycin. Anti-MSSA antibiotics include anti-staphylococcal antibiotics typically ineffective against CA-MRSA (penicillins, cephalosporins, macrolides, fluoroquinolones).