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Table 1 Meta-analysis of effects of rhAPC on 28-day mortality in patients with severe sepsis and APACHE II score of ≥25 at study entry

From: A meta-analysis of controlled trials of recombinant human activated protein C therapy in patients with sepsis

Clinical Trial N rhAPC Control RR 95% CI p-Value
PROWESS 817 30.9 43.7 0.71 0.59 – 0.85 0.0002 1
ADDRESS 324 29.7 24.5 1.21 0.85 – 1.74 0.32 1
Total 1141 30.6 38.3 0.80 0.68 – 0.94 0.007 1,2,3
  1. 1 two-sided Fishers exact test
  2. 2 Cochran-Mantel-Haenszel test, p = 0.006
  3. 3 Breslow-Day test homogeneity, p = 0.005.