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Table 1 Meta-analysis of effects of rhAPC on 28-day mortality in patients with severe sepsis and APACHE II score of ≥25 at study entry

From: A meta-analysis of controlled trials of recombinant human activated protein C therapy in patients with sepsis

Clinical Trial

N

rhAPC

Control

RR

95% CI

p-Value

PROWESS

817

30.9

43.7

0.71

0.59 – 0.85

0.0002 1

ADDRESS

324

29.7

24.5

1.21

0.85 – 1.74

0.32 1

Total

1141

30.6

38.3

0.80

0.68 – 0.94

0.007 1,2,3

  1. 1 two-sided Fishers exact test
  2. 2 Cochran-Mantel-Haenszel test, p = 0.006
  3. 3 Breslow-Day test homogeneity, p = 0.005.
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BMC Emergency Medicine

ISSN: 1471-227X

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