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Table 1 Characteristics of included randomized trials

From: Systematic review of randomized clinical trials on the use of hydroxyethyl starch for fluid management in sepsis

Trial n Indication Fluid Regimen Follow-Up Endpoints
Falk et al., 1988 [9] 12 Septic shock 6% HES 450/0.7 or 5% albumin to 15 mm Hg target PAWP 24 h Coagulation
Rackow et al., 1989 [7] 20 Severe sepsis and systemic hypoperfusion 10% HES 200/0.5 or 5% albumin to 15 mm Hg target PAWP or 2000 mL maximum 45 min Cardiorespiratory function and coagulation
Boldt et al., 1995 [17,18] 30 Sepsis after major surgery 10% HES 200/0.5 or 20% albumin to 12–16 mm Hg target CVP, PCWP or both 5 days Endothelial-related coagulation and platelet function
Boldt et al., 1996 [19] 30 Sepsis secondary to major general surgery 10% HES 200/0.5 or 20% albumin to 12–18 mm Hg target PCWP 5 days Cardiorespiratory and circulatory variables
Boldt et al., 1996 [20] 42 Sepsis secondary to major surgery 6% HES 200/0.5, 20% albumin or pentoxifylline 5 days Circulating soluble adhesion molecules
Boldt et al., 1996 [21] 28 Sepsis secondary to major surgery 10% HES 200/0.5 or 20% albumin to 10–15 mm Hg target PCWP 5 days Circulatory variables
Boldt et al., 1998 [22] 150 Postoperative sepsis 10% HES 200/0.5 or 20% albumin to 12–15 mm Hg target PCWP 5 days Hemodynamics, laboratory data and organ function
Asfar et al., 2000 [23] 34 Sepsis and hypovolemia in ventilated and hemodynamically controlled patients 500 mL 6% HES 200/0.62 or 4% succinylated modified fluid gelatin 60 min Hemodynamics and gastric mucosal acidosis
Schortgen et al., 2001 [24] 129 Severe sepsis or septic shock 6% HES 200/0.62 up to 4 days or 80 mL·kg-1 cumulative dose or 3% gelatin 34 days ARF
Molnár et al., 2004 [25] 30 Septic shock with hypovolemia and acute lung injury 6% HES 200/0.5 or 4% modified fluid gelatin to achieve ITBVI > 900 mL·m-2 60 min Hemodynamics, EVLW and oxygenation
Palumbo et al., 2006 [26] 20 Severe sepsis in mechanically ventilated patients 6% HES 130/0.4 or 20% albumin to maintain PCWP of 15–18 mm Hg 5 days Hemodynamic and oxygenation parameters
Brunkhorst et al., 2008 [27] 537 Severe sepsis or septic shock 10% HES 200/0.5 (to 20 mL·kg-1·day-1 limit) or Ringer's lactate to target of ≥ 8 mm Hg CVP 90 days Morbidity and mortality
  1. Abbreviations: ARF, acute renal failure; CVP, central venous pressure; EVLW, extravascular lung water; HES, hydroxyethyl starch; ICU, intensive care unit; ITBVI, intrathoracic blood volume index; PAWP, pulmonary arterial wedge pressure; PCWP, pulmonary capillary wedge pressure
  2. For trials with more than one indication, includes only patients with sepsis.
  3. HES solutions specified by molecular weight/molar substitution.