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Table 3 Sensitivity, specificity and ROC area under the curve for AG, ACAG & BD.

From: Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia

Variable

ROC AUC

CIs

  

Anion Gap

0.70

0.64 – 0.77

  

ACAG

0.72

0.62 – 0.82

  

Base Deficit

0.79

0.73 – 0.85

  

Variable

Threshold

Sensitivity

Specificity

NPV

Anion Gap

10

63.0%

65.4%

90.0%

 

12

51.9%

80.0%

90.0%

 

14

39.5%

88.7%

88.2%

 

16

27.2%

94.0%

87.0%

ACAG

10

94.4%

15.5%

99.4%

 

12

88.9%

29.2%

95.3%

 

14

75.0%

53.5%

94.2%

 

16

55.6%

74.9%

92.8%

Base Deficit

2

81.5%

66.8%

94.9%

 

4

63.0%

80.4%

91.8%

 

6

50.6%

88.1%

90.2%

 

8

40.7%

91.6%

88.8%

  1. Hyperlactatemia defined as serum lactate > 2.5 mmol/L
  2. ROC AUC = Receiver operator characteristics area under the curve, AG = anion gap, ACAG = anion gap corrected for albumin, BD = Base Deficit, CI = 95% confidence intervals, NPV = negative predictive value