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Table 3 Sensitivity, specificity and ROC area under the curve for AG, ACAG & BD.

From: Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia

Variable ROC AUC CIs   
Anion Gap 0.70 0.64 – 0.77   
ACAG 0.72 0.62 – 0.82   
Base Deficit 0.79 0.73 – 0.85   
Variable Threshold Sensitivity Specificity NPV
Anion Gap 10 63.0% 65.4% 90.0%
  12 51.9% 80.0% 90.0%
  14 39.5% 88.7% 88.2%
  16 27.2% 94.0% 87.0%
ACAG 10 94.4% 15.5% 99.4%
  12 88.9% 29.2% 95.3%
  14 75.0% 53.5% 94.2%
  16 55.6% 74.9% 92.8%
Base Deficit 2 81.5% 66.8% 94.9%
  4 63.0% 80.4% 91.8%
  6 50.6% 88.1% 90.2%
  8 40.7% 91.6% 88.8%
  1. Hyperlactatemia defined as serum lactate > 2.5 mmol/L
  2. ROC AUC = Receiver operator characteristics area under the curve, AG = anion gap, ACAG = anion gap corrected for albumin, BD = Base Deficit, CI = 95% confidence intervals, NPV = negative predictive value
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