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Table 4 Sensitivity, specificity and ROC area under the curve for AG, ACAG & BD.

From: Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia

Variable

ROC AUC

CIs

  

Anion Gap

0.87

0.82 – 0.93

  

ACAG

0.95

0.91–0.99

  

Base Deficit

0.78

0.71 – 0.86

  

Variable

Threshold

Sensitivity

Specificity

NPV

Anion Gap

10

88.9%

65.7%

98.3%

 

12

82.2%

80.4%

97.8%

 

14

66.7%

89.2%

96.4%

 

16

48.9%

94.5%

94.9%

ACAG

10

100%

15.1%

100%

 

12

100%

29.8%

100%

 

14

100%

51.5%

100%

 

16

92.9%

74.4%

99.5%

Base Deficit

2

84.4%

63.3%

97.6%

 

4

64.4%

77.1%

95.6%

 

6

51.1%

84.5%

94.5%

 

8

42.2%

89.5%

93.9%

  1. Hyperlactatemia defined as Lactate > 4.0 mmol/L
  2. ROC AUC = Receiver operator characteristics area under the curve, AG = anion gap, ACAG = anion gap corrected for albumin, BD = Base Deficit, CI = 95% confidence intervals, NPV = Negative Predictive Value