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Table 4 Sensitivity, specificity and ROC area under the curve for AG, ACAG & BD.

From: Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia

Variable ROC AUC CIs   
Anion Gap 0.87 0.82 – 0.93   
ACAG 0.95 0.91–0.99   
Base Deficit 0.78 0.71 – 0.86   
Variable Threshold Sensitivity Specificity NPV
Anion Gap 10 88.9% 65.7% 98.3%
  12 82.2% 80.4% 97.8%
  14 66.7% 89.2% 96.4%
  16 48.9% 94.5% 94.9%
ACAG 10 100% 15.1% 100%
  12 100% 29.8% 100%
  14 100% 51.5% 100%
  16 92.9% 74.4% 99.5%
Base Deficit 2 84.4% 63.3% 97.6%
  4 64.4% 77.1% 95.6%
  6 51.1% 84.5% 94.5%
  8 42.2% 89.5% 93.9%
  1. Hyperlactatemia defined as Lactate > 4.0 mmol/L
  2. ROC AUC = Receiver operator characteristics area under the curve, AG = anion gap, ACAG = anion gap corrected for albumin, BD = Base Deficit, CI = 95% confidence intervals, NPV = Negative Predictive Value
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