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Table 2 Acute Kidney Injury (AKI) at two and seven days related to Proenkephalin A 119–159 (penKid)

From: Proenkephalin a 119–159 (penKid) – a novel biomarker for acute kidney injury in sepsis: an observational study

 

All patients

(n = 588)

P-value

Quartile 1

(n = 147)

Quartile 2

(n = 147)

Quartile 3

(n = 147)

Quartile 4

(n = 147)

P for trend

penKid (pmol/L)a

77.9 (10.9–843.0)

 

10.9–56.9

57.0–77.9

78.1–119.4

120.0–843.0

 

AKI within 2 days

 N events (% of total) b

79 (13.4%)

 

9 (6.1%)

6 (4.1%)

14 (9.5%)

50 (34.0%)

 

 OR (95% CI)c

2.5 (1.9–3.3)

< 0.001

Reference

0.7 (0.2–1.9)

1.7 (0.7–4.2)

8.5 (3.7–19.2)

< 0.001

AKI within 7 days

 N events (% of total)b

94 (15.9%)

 

10 (1.7%)

8 (1.4%)

17 (2.9%)

59 (10.0%)

 

 OR (95% CI)c

2.5 (1.9–3.2)

< 0.001

Reference

0.8 (0.3–2.0)

1.9 (0.8–4.3)

9.5 (4.3–20.7)

< 0.001

  1. aPenKid presented as median (range), plasma concentration of proenkephalin A 119–159; OR, odds ratio; 95% CI, 95% confidence interval. bN (% of total) refers to the number of participants (proportion of total number participants) with Acute Kidney Injury (AKI) events. cOR (95% CI) are expressed as per z-score of log-transformed penKid and in analyses of quartiles the lowest quartile (quartile 1) was defined as the reference category and the OR (95% CI) for each of quartiles 2, 3 and 4 were compared with the reference quartile 1. Analyses were adjusted for age and sex
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BMC Emergency Medicine

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