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Table 2 Routes of administration and dose of naloxone in 2215 suspected cases of opioid overdose and subsequent administration of naloxone after the initial dose

From: Prehospital naloxone administration – what influences choice of dose and route of administration?

Initial naloxone treatment

% (n)

Subsequent naloxone administration, % (n)

Total

100 (2215)

15.0 (332)

IM only

91.9 (2035)

15.6 (318)

 0.4 mg

39.9 (811)

16.5 (134)

 0.8 mg

56.5 (1150)

15.0 (172)

 Other doses < 0.8 mg

3.5 (72)

 

 Other doses > 0.8 mg

0.1 (2)

 

IV only

1.9 (41)

9.8 (4)

 0.4 mg

75.6 (31)

 

 0.8 mg

17.1 (7)

 

 Other doses < 0.8 mg

7.3 (3)

 

IM and IV

3.8 (84)

2.4 (2)

 0.4 IM + 0.4 IV

17.9 (15)

 

 0.8 IM + 0.4 IV

65.5 (55)

 

 0.8 IM + 0.8 IV

10.7 (9)

 

 Other doses > 0.8 mg

6.0 (5)

 

Other

2.5 (55)

14.6 (8)

  1. IM = intramuscular, IV = intravenous