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Table 6 Patients stratified by bleed type

From: Comparison of 3-factor versus 4-factor prothrombin complex concentrate for emergent warfarin reversal: a systematic review and meta-analysis

Study, Year

ICH PCC3

ICH PCC4

GIB PCC3

GIB PCC4

Other PCC3

Other PCC4

Not listed PCC3

Not listed PCC4

Al-Majzoub et al., 2016 [20]

26 (74.3%)

12 (66.7%)

7 (20%)

2 (11.1%)

2 (5.1%)

3 (16.7%)

NR

NR

DeAngelo et al., 2018 [22]

21 (61.8%)

10 (76.9%)

0 (0%)

2 (15.4%)

2 (5.9%)

1 (7.7%)

Thoracic 2 (5.9%), genitourinary GU 1 (2.9%), intraabdominal and retroperitoneal 8 (23.5%)

0 (0%)

Fischer et al., 2018 [24]

100%

100%

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

Holt et al., 2018 [25]

48 (62%)

23 (40%)

5 (7%)

14 (24%)

13 (16%)

4 (7%)

Chest Bleeds = 4 (6%)

Multiple = 7 (9%)

Missing = 0

Chest Bleeds PCC4 = 0

Multiple = 15 (25%)

Missing = 1 (2%)

Jones et al., 2016 [27]

80 (95.2%)

40 (62.5%)

2 (2.4%)

11 (17.2%)

2 (2.4%)

13 (20.3%)

NR

NR

Kuroski et al., 2017 [28]

48 (70.6%)

54 (78.3%)

4 (5.9%)

2 (2.9%)

12 (17.6%)

10 (14.5%)

Retroperitoneal: 2 (2.9%), Emergent Surgery: 2 (2.9%)

Retroperitoneal: 2 (2.9%), Emergent Surgery: 1 (1.4%)

Mangram et al., 2016 [30]*

NR

NR

NR

NR

NR

NR

NR

NR

Margraf et al., 2020 [31]

31 (54.4%)

19 (82.6%)

10 (17.5%)

2 (8.7%)

16 (28.1%)

2 (8.7%)

NR

NR

Mohan et al., 2018 [32]

45 (35%) (both groups)

45 (35%) (both groups)

33 (26%) (both groups)

33 (26%) (both groups)

29 (23%) (both groups)

29 (23%) (both groups)

Periprocedural 21 (16%) (both groups)

Periprocedural 21 (16%) (both groups)

Voils et al., 2015 [33]

65 (60%)

34 (61%)

7 (6%)

10 (18%)

6 (6%)

0 (0%)

IA/thoracic 12 (11%)

IA/thoracic 8 (14%)

Cang et al., 2014 [21]

NR

NR

NR

NR

NR

NR

NR

NR

Di Napoli et al., 2014 [23]

51 (100%)

18 (100%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

NR

Kotsianas et al., 2015 [26]

100%

100%

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

Peck et al., 2016 [29]

100%

100%

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

Wagner et al., 2019 [34]

62%

50%

NR

NR

NR

NR

NR

NR

  1. GIB gastrointestinal bleeding, ICH intracerebral hemorrhage, INR international normalized ratio, NR not reported, PCC prothrombin complex concentrate, PCC3 3 factor PCC, PCC4 4 factor PCC