Fig. 2

Age-stratified analyses of the analgesic and sedative effects of sufentanil and nalbuphine on ICU patients. Pain intensity in ICU patients who received nalbuphine or sufentanil at different time points under 60 (A) and over 60 years of age (B). Sedation/restlessness intensity in ICU patients who received nalbuphine or sufentanil at different time points under 60 (C) and over 60 years of age (D). Data were expressed as mean ± SD. The P-value was calculated using the generalized estimating equation method. The asterisk indicates that there is a significant difference between the groups at the specified time point