Table 6 Selected estimation results: main sample by comparison

Estimation Sample

 Patients

423

753

423

802

423

278

 Observations

2907

3211

1934

Variable

 Ineligibilities

  Under 18 (Yes = 1)

-0.064

-

-0.053

-

-0.075

-

  Pain mild/none (Yes = 1)

-1.862**

-

-1.776**

-

-1.929**

-

  GCS ineligible/missing (Yes = 1)

-0.779**

-

-0.740**

-

-0.796**

-

  Trauma ineligible (Yes = 1)

0.284

-

0.271

-

0.312

-

 Demographics

  Sex (F = 0, M = 1)

-0.402**

-0.285**

-0.387**

-0.048

-0.409**

-0.232

  Age (years)

-0.003

-0.002

-0.003

-0.001

-0.003

-0.002

  Trauma #1 (Yes = 1)

(reference)

(reference)

(reference)

(reference)

(reference)

(reference)

  Trauma #2 (Yes = 1)

-0.152

0.222

-0.143

-0.157

-0.154

-0.228

  Trauma #3 (Yes = 1)

-0.362*

0.019

-0.344*

-0.229

-0.359*

-0.136

  Trauma #4 (Yes = 1)

-0.537**

-0.038

-0.502**

-0.187

-0.528**

-0.090

  Trauma #5 (Yes = 1)

-0.048

0.062

-0.042

0.248

-0.041

-0.211

  Trauma #6 (Yes = 1)

-0.650

-0.048

-0.622

-0.047

-0.658

0.181

 Pathways

  Time, \(t\)

-0.071**

-0.108**

-0.081**

  Time squared, \({t}^{2}\)

0.001**

0.001**

0.001**

  Methoxyflurane, \(d\)

0.730**

-

0.422

-

0.914**

-

  Methoxyflurane x Time, \(dt\)

-0.135**

-

-0.088**

-

-0.128**

-

  Methoxyflurane x Time², \(d{t}^{2}\)

0.003**

-

0.002**

-

0.003**

-

 Medicine Use

  Nonadherence (Yes = 1)

0.707*

-

0.674*

-

0.724*

-

  Side-effect (Yes = 1)

0.064

-

0.069

-

0.085

-

  Discontinue early (Yes = 1)

0.399

-

0.372

-

0.402

-

  Influence Entonox® (Yes = 1)

-0.046

-

-0.019

-

-0.051

-

  Influence potency 1 (Yes = 1)

0.003

-

-0.003

-

0.001

-

  Influence potency 2 (Yes = 1)

-0.003

-

-0.006

-

-0.004

-

  Influence potency 3 (Yes = 1)

0.253

-

0.237

-

0.270

-