Table 3 Univariate and multivariate Cox proportional hazards analysis of predictors of the primary outcome

Age (each 10 years)

1.28 (1.01–1.61)

1.13 (0.89–1.44)

Female sex (yes/no)

1.15 (0.64–2.08)

-

Past or active smoker (yes/no)

0.39 (0.10–1.62)

-

Comorbidities (yes/no):

 • Obesity

0.99 (0.54–1.82)

-

 • Hypertension

1.67 (0.90–3.12)

-

 • Diabetes

1.92 (1.05–3.49)

1.30 (0.68–2.50)

 • Neoplasia

0.34 (0.05–2.47)

-

 • Past coronary artery disease

1.36 (0.61–3.02)

-

 • Past cerebrovascular disease

1.22 (0.46–3.60)

-

 • Chronic kidney disease

1.87 (1.06–3.30)

-

COVID-19

 • Moderate (Reference)

1

1

 • Severe

2.09 (1.13–3.85)

1.96 (1.05–3.65)

Hemoglobin (each 1 g/dl)

0.86 (0.73–1.02)

0.97 (0.80–1.18)

Platelet count (each 10⁴/mm³)

0.97 (0.93–1.01)

-

eGFR (each 10 ml/min/1.73m²)

0.87 (0.78–0.96)

0.94 (0.83–1.06)

D-dimer (each log ng/dl FEU)

1.55 (1.20–2.00)

1.38 (1.04–1.84)

Prothrombin time (each log INR)

5.29 (0.74–38)

5.72 (0.84–39)

Heparin use

 • Low dose (reference)

1

1

 • Intermediate/high dose

1.47 (0.82–2.63)

1.44 (0.79–2.62)

Antiplatelet drugs (yes/no)

1.44 (0.81–2.55)

-

Statins (yes/no)

0.74 (0.36–1.53)

-