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Table 1 Screening of potential false negatives

From: The application of an age adjusted D-dimer threshold to rule out suspected venous thromboembolism (VTE) in an emergency department setting: a retrospective diagnostic cohort study

Patient Age

D-dimer result (FEU)

Age Adjusted Cut off (age × 10) (FEU)

Well’s Score

Reference Standing Imaging

Decision

91

572

910

Not calculated (however DVT was listed as number listed differential)

CUS- partial non occlusive common femoral vein DVT

Exclude- high clinical suspicion and non-occlusive thrombus

89

496

890

6

CTPA- VTE positive

Exclude- high pre-test probability

85

622

850

Not calculated. However high risk as previous DVT

CUS- VTE positive

Exclude- non occlusive thrombus

85

654

850

2

CUS- small non occlusive thrombus suggested

Exclude- non occlusive thrombus

81

592

810

Not calculated. Immediately post operatively

CUS– non occlusive chronic thrombus

Exclude – chronic thrombus

76

642

760

Not calculated. 3 week history of thrombophlebitis

CUS- positive for thrombophlebitis

Exclude- thrombophlebitis

75

300

750

Not calculated

CUS- non occlusive chronic thrombus

Exclude- chronic thrombus

75

544

750

5

CUS- VTE positive

Exclude- high pre-test probability

77

704

770

Not calculated. 4 from data available

CUS- VTE positive

Exclude- high pre-test probability

53

504

530

Not calculated

CTPA – VTE positive

Include as false negative

46

462

460

Not calculated

CUS- VTE positive, however repeat scan negative

Exclude patient < 50 so normal cut off would be used

73

670

730

Not calculated. 2–3 day history of swollen ankle. Received subcutaneous thromboplastin

CUS- VTE positive

Exclude – high pre-test probability

84

634

840

Not calculated. No data available

CTPA- VTE positive

Include as false negative

84

628

840

Not calculated No data available

CTPA- VTE positive

Exclude- repeat CTPA in the above patient during same admission

60

600

600

-1

CUS- VTE positive

Include as a false negative

88

480

880

2, high clinical suspicion

CUS- VTE positive

Exclude- high pre-test probability

84

764

840

3

CUS- VTE positive

Exclude- high pre-test probability

83

692

830

3

CUS- VTE positive

Exclude- high pre-test probability

76

656

760

Not calculated

CUS- partial non occlusive thrombus in the superficial femoral vein – not treated

Exclude- non occlusive thrombus. Not treated

93

546

930

3

CUS- VTE positive

Exclude-high pre-test probability

  1. *FEU refers to fibrinogen equivalent units
  2. *Age adjusted D-dimer threshold calculation (age in years × 10) in FEU