OBSERvE-DUS n = 621 | OBSERvE-1 [6] n = 532 | OBSERvE 2 [7] n = 457 | Kreß et al. [4] n = 193 | p (*Student-t-test, #χ²-test) | |
---|---|---|---|---|---|
Study information | |||||
Study design | single-center retrospective cohort study | single-center prospective observational cohort study | single-center prospective observational cohort study | single-center retrospective cohort study | |
Study period (months) | 12 | 12 | 12 | 6 | |
Study setting (type) | tertiary-care university hospital | tertiary-care university hospital | tertiary-care university hospital | academic teaching hospital | |
Case load (n) | 40,764 | 34,303 | 35,039 | 19,854 | |
Case load of critically ill non-traumatic patients [n, (%)] | 621 (1.5) | 532 (1.6) | 457 (1.3) | 193 (1.0) | #a0.8909, #b0.7836, #c0.6034 |
Patient´s characteristics | |||||
Age (years, MV ± SD) | 70 ± 16 | 67 ± 17 | 65 ± 17 | 66 ± 16 | *a0.0021, *b<0.0001, *c0.0025 |
Sex, male [n, (%)] | 323 (52.0) | 310 (58.3) | 273 (59.7) | 106 (54.9) | #a0.1114, #b0.0597, #c0.6042 |
NACA [n, (%)] | 539 (86.8) | 489 (92.0) | 388 (85.0) | not reported | #a0.0072, #b0.4355, #c n.a. |
Admission by EMS [n, (%)] | 578 (93.1) | 498 (93.6) | 438 (93.7) | not reported | #a0.7432, #b0.7038, #c n.a. |
ABCDE problems [n, (%)] | |||||
A (airway) | 12 (1.9) | 20 (3.8) | 17 (3.7) | not reported | #a0.7672, #b0.7818, #cn.a. |
B (breathing) | 152 (24.5) | 141 (26.5) | 132 (28.8) | not reported | #a0.6951, #b0.4803, #cn.a. |
C (circulation) | 194 (31.2) | 189 (35.5) | 160 (35.1) | not reported | #a0.3727, #b0.4379, #cn.a. |
D (disability) | 256 (41.2) | 177 (33.3) | 146 (31.9) | not reported | #a0.0963, #b0.0648, #cn.a. |
E (environment) | 7 (1.1) | 5 (0.9) | 2 (0.4) | not reported | #a0.9740, #b0.9322, #cn.a. |
Vital signs admission [MV ± SD] | |||||
Systolic blood pressure (mmHg) | 129 ± 45 | 135 ± 44 | 136 ± 40 | 131 ± 45 | *a0.0228, *b0.0083, *c0.5898 |
Heart rate (bpm) | 95 ± 35 | 96 ± 30 | 99 ± 32 | 95 ± 33 | *a0.6058, *b0.0548, *c1.0000 |
Shock index (bpm/mmHg) | 0.8 ± 0.5 | 0.8 ± 0.5 | 0.8 ± 0.4 | not reported | *a1.0000, *b1.0000,*cn.a |
Oxygen saturation (%) | 94 ± 8 | 92 ± 11 | 94 ± 10 | 91 ± 10 | *a0.0004, *b1.0000, *c<0.0001 |
Respiratory rate (min− 1) | 22 ± 13 | 20 ± 10 | 20 ± 9 | 22 ± 9 | *a0.0039, *b0.0048, *c1.0000 |
Glasgow coma score (points) | 10 ± 5 | 8 ± 5 | 8 ± 5 | 11 ± 4 | *a<0.0001, *b<0.0001,*c0.0114 |
Temperature tympanal (°C) | 36 ± 2 | 36 ± 1 | 37 ± 2 | not reported | **a1.0000, *b<0.0001, *cn.a |
ROSC at admission [n, (%)] | 52 (71.2) | 55 (60.4) | 43 (47.3) | not reported | #a<0.0001, #b<0.0001, #cn.a |