Variable | Methoxyflurane Cohort (1) (N = 1236) | Concurrent Cohort (2) (N = 1101) | Non-concurrent Cohort (3) (N = 45112) | p-value (1) vs. (2) | p-value (1) vs. (3) |
---|---|---|---|---|---|
All Renal Events | |||||
No. of patients with events | 28 | 62 | 1450 | - | - |
% of patients (95% CI) | 2.3 (1.4, 3.1) | 5.6 (4.3, 7.0) | 3.2 (3.1, 3.4) | < 0.001 | 0.070 |
Incidence Rate for All Renal Events | |||||
No. of valid patientsa | 1221 | 1039 | 45112 | - | - |
No. of patients with events (%) | 26 (2.13) | 52 (5.00) | 1450 (3.21) | - | - |
Incidence rate (patient-month) (95% CI) | 7.89 (5.15, 11.56) | 18.76 (14.01, 24.61) | 11.98 (11.37, 12.61) | < 0.001 | 0.034 |
Incidence rate ratiob (95% CI) | - | 2.38 (1.49, 3.81) | 1.52 (1.03, 2.24) | - | - |
Confirmed Renal Events | |||||
No. of patients with events | 9 | 29 | 1106 | ||
% of patients (95% CI) | 0.7 (0.3, 1.2) | 2.6 (1.7, 3.6) | 2.5 (2.3, 2.6) | < 0.001 | < 0.001 |
Incidence Rate for Confirmed Renal Events | |||||
No. of valid patientsa | 1223 | 1048 | 45112 | - | - |
No. of patients with events (%) | 9 (0.74) | 28 (2.67) | 1106 (2.45) | - | - |
Incidence rate (patient-month) (95% CI) | 2.69 (1.23, 5.10) | 9.84 (6.54, 14.23) | 9.09 (8.56, 9.64) | 0.004 | < 0.001 |
Incidence rate ratiob (95% CI) | - | 3.66 (1.72, 7.56) | 3.38 (1.75, 6.52) | - | - |